Congenic regions and incidence of sialadenitis in congenic mice and healthy controls. (a) The location of the two nonobese diabetic (NOD) fragments Idd5 and Nss1 on chromosome (Chr.) 1 and Chr. 4, respectively. (b) The severity of sialadenitis, represented by the Sialadenitis Ratio Index (SRI), which is the total focus area (mm2) divided by the total gland area (mm2). The strains are B10.Q (n = 10), B10.Q.Nss1 (NB; n = 4), B10.Q.Nss1/Idd5-he (NBI-he; n = 4) and B10.Q.Nss1/Idd5-ho (NBI-ho; n = 7). The numbers and each of the bars represent mean values of SRI for each group, the error bars show standard error of the mean, and statistically significant increase compared with B10.Q is indicated by asterisk (analysis of variance with Dunnet's post hoc test; P = 0.017).