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Table 5 Genes differentially expressed between female and male OA and control bone samples

From: Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-β/bone morphogenic protein signalling

GenBank Role Cell type Symbol Name t OAF/OAM t OA/CTL t OA/OP
Differentially expressed genes in top 20 regulated genes
NM_000177 B OC GSN Gelsolin 5.983 4.725 -2.387
NM_001078 B OB, OC VCAM1 Vascular cell adhesion molecule 1 5.158 -1.358 -2.377
NM_006764    IFRD2 Interferon-related developmental regulator 2 -5.081 4.274 2.162
NM_018456    EAF2 ELL associated factor 2 4.574 6.450 0.884
NM_002087 B OC GRN Granulin 4.562 11.161 -2.008
NM_000211 B OC ITGB2 Integrin, beta 2 (CD18) 4.378 6.104 -1.243
NM_004203    PKMYT1 Protein kinase, membrane associated tyrosine/threonine 1 -4.373 -3.375 1.741
NM_001329    CTBP2 C-terminal binding protein 2 -4.339 1.548 4.057
NM_006202 B OB, OC PDE4A Phosphodiesterase 4A -4.131 -1.565 3.337
NM_017845    COMMD8 COMM domain containing 8 4.118 3.264 -0.398
AY009399 B, C OB, OC, CB WNT5B Wingless-type MMTV integration site family, member 5B 4.107 3.719 0.717
NM_002822 B OC PTK9 PTK9 protein tyrosine kinase 9 4.099 -0.597 -5.894
NM_002343 B OB LTF Lactotransferrin 4.096 4.918 1.882
Additional differentially expressed genes in top 50 regulated genes
NM_005606 A, B OB, OC LGMN Legumain 3.853 9.631 -4.470
NM_015946 A, B, C OB, CB ITGA1 Integrin, alpha 1 3.813 3.904 0.131
NM_004039 B OB, OC ANXA2 Annexin A2 3.754 5.716 -7.601
M14087 A, B OB LGALS1 Lectin, galactoside-binding, soluble, 3.705 4.583 -0.045
NM_006079 A, B OB CITED2 Cbp/p300-interacting transactivator with Glu/Asp-rich domain 2 3.591 8.580 -1.403
M38449 A, B, C OB, OC, CB TGFB1 Transforming growth factor, beta 1 -3.575 2.739 3.054
Z15114 A, B OB PRKCG Protein kinase C, gamma -3.570 0.018 3.741
NM_003639 B OC IKBKG I kappa B kinase gamma 3.376 6.775 -1.704
AK026898 B OC FOXP1 Forkhead box P1 -3.348 -5.122 1.761
NM_001928 B OB DF D component of complement (adipsin) 3.306 6.851 -0.991
NM_006037 B OB HDAC4 Histone deacetylase 4 3.272 8.475 2.468
NM_001742 B OC CALCR Calcitonin receptor -3.036 0.663 1.800
Not detected by microarray to be differentially regulated between females and males
NM_004142 A, B, C OB, OC, CB MMP25 Matrix metalloproteinase 25 0.237 4.942 7.183
  1. 'Role' indicates the known or suspected role of the gene: A, angiogenic; B, osteogenic; and C, chondrogenic. 'Cell type' indicates the cell type that the gene is expressed in or affects: OB, osteoblast, OC, osteoclast, OS, osteocyte, or CB, chondroblast. 't OAF/OAM' is the t score of osteoarthritis (OA) female compared with OA male differential expression of gene: a postive value indicates upregulation in OA female and a negative one indicates downregulation in OA female. 't OA/CTL' is the t score of OA compared with CTL differential expression of gene: a positive value indicates upregulation in OA and a negative one indicates downregulation in OA. 't OA/OP' is the t score of OA compared with osteoporosis (OP) differential expression of gene: a positive value indicates upregulation in OA and a negative one indicates downregulation in OA. The moderated t-statistic score is based on the ratio of the log2 fold change to its standard error.