Skip to main content

Table 5 Genes differentially expressed between female and male OA and control bone samples

From: Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-β/bone morphogenic protein signalling

GenBank

Role

Cell type

Symbol

Name

t OAF/OAM

t OA/CTL

t OA/OP

Differentially expressed genes in top 20 regulated genes

NM_000177

B

OC

GSN

Gelsolin

5.983

4.725

-2.387

NM_001078

B

OB, OC

VCAM1

Vascular cell adhesion molecule 1

5.158

-1.358

-2.377

NM_006764

  

IFRD2

Interferon-related developmental regulator 2

-5.081

4.274

2.162

NM_018456

  

EAF2

ELL associated factor 2

4.574

6.450

0.884

NM_002087

B

OC

GRN

Granulin

4.562

11.161

-2.008

NM_000211

B

OC

ITGB2

Integrin, beta 2 (CD18)

4.378

6.104

-1.243

NM_004203

  

PKMYT1

Protein kinase, membrane associated tyrosine/threonine 1

-4.373

-3.375

1.741

NM_001329

  

CTBP2

C-terminal binding protein 2

-4.339

1.548

4.057

NM_006202

B

OB, OC

PDE4A

Phosphodiesterase 4A

-4.131

-1.565

3.337

NM_017845

  

COMMD8

COMM domain containing 8

4.118

3.264

-0.398

AY009399

B, C

OB, OC, CB

WNT5B

Wingless-type MMTV integration site family, member 5B

4.107

3.719

0.717

NM_002822

B

OC

PTK9

PTK9 protein tyrosine kinase 9

4.099

-0.597

-5.894

NM_002343

B

OB

LTF

Lactotransferrin

4.096

4.918

1.882

Additional differentially expressed genes in top 50 regulated genes

NM_005606

A, B

OB, OC

LGMN

Legumain

3.853

9.631

-4.470

NM_015946

A, B, C

OB, CB

ITGA1

Integrin, alpha 1

3.813

3.904

0.131

NM_004039

B

OB, OC

ANXA2

Annexin A2

3.754

5.716

-7.601

M14087

A, B

OB

LGALS1

Lectin, galactoside-binding, soluble,

3.705

4.583

-0.045

NM_006079

A, B

OB

CITED2

Cbp/p300-interacting transactivator with Glu/Asp-rich domain 2

3.591

8.580

-1.403

M38449

A, B, C

OB, OC, CB

TGFB1

Transforming growth factor, beta 1

-3.575

2.739

3.054

Z15114

A, B

OB

PRKCG

Protein kinase C, gamma

-3.570

0.018

3.741

NM_003639

B

OC

IKBKG

I kappa B kinase gamma

3.376

6.775

-1.704

AK026898

B

OC

FOXP1

Forkhead box P1

-3.348

-5.122

1.761

NM_001928

B

OB

DF

D component of complement (adipsin)

3.306

6.851

-0.991

NM_006037

B

OB

HDAC4

Histone deacetylase 4

3.272

8.475

2.468

NM_001742

B

OC

CALCR

Calcitonin receptor

-3.036

0.663

1.800

Not detected by microarray to be differentially regulated between females and males

NM_004142

A, B, C

OB, OC, CB

MMP25

Matrix metalloproteinase 25

0.237

4.942

7.183

  1. 'Role' indicates the known or suspected role of the gene: A, angiogenic; B, osteogenic; and C, chondrogenic. 'Cell type' indicates the cell type that the gene is expressed in or affects: OB, osteoblast, OC, osteoclast, OS, osteocyte, or CB, chondroblast. 't OAF/OAM' is the t score of osteoarthritis (OA) female compared with OA male differential expression of gene: a postive value indicates upregulation in OA female and a negative one indicates downregulation in OA female. 't OA/CTL' is the t score of OA compared with CTL differential expression of gene: a positive value indicates upregulation in OA and a negative one indicates downregulation in OA. 't OA/OP' is the t score of OA compared with osteoporosis (OP) differential expression of gene: a positive value indicates upregulation in OA and a negative one indicates downregulation in OA. The moderated t-statistic score is based on the ratio of the log2 fold change to its standard error.