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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Immunohistological assessment of the synovial tissue in small joints in rheumatoid arthritis: validation of a minimally invasive ultrasound-guided synovial biopsy procedure

Figure 2

Evaluation of the minimum area required for quantitative analyses of CD68, CD3 and CD20 cells. For each of the tissue markers studied, a plot was generated to show the effects of increasing sample size (that is, the number of high-power fields examined) and the proximity of this sample mean from the overall determination of area fraction. Data represent the mean values of all cases. As the number of high-power fields examined increases, the difference between the sampling mean and the overall mean reduces. A threshold value of 10% of the overall mean (arrows) was set as providing a reasonable estimator of the true sample mean.

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