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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling

Figure 3

Proteoglycan content after Ad-BMP-2 injection. Knee joints of mice injected with Ad-BMP-2 or a control virus were isolated at days 3, 7, or 21 and processed for histology. Sections were stained with safranin O and fast green, after which safranin O staining intensity was measured in the articular cartilage with a computerized imaging system as a measurement of proteoglycan content of the cartilage. At least three sections per knee joint were measured. Measurements were averaged per knee joint. Statistical analysis with a Student t test. *p < 0.05. BMP-2, bone morphogenetic protein-2.

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Arthritis Research & Therapy

ISSN: 1478-6362

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