Skip to main content
Figure 4 | Arthritis Research & Therapy

Figure 4

From: Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling

Figure 4

Effect of bone morphogenetic protein-2 (BMP-2) on cartilage matrix degradation. Immunohistochemistry for VDIPEN and NITEGE was performed on paraffin sections of knee joints 3, 7, and 21 days after Ad-BMP-2 or Ad-luc injection. The area of the cartilage staining positive was determined with a computerized imaging system. BMP-2 was compared to controls and shows an increase in VDIPEN staining on days 3 and 7 in patellar cartilage, which was only significant and most prominent on day 7. The elevated VDIPEN staining had reversed by day 21 to levels lower than those of controls. (a) NITEGE staining was low on day 3 but was clearly elevated by day 7 on the patella. This was reduced by more than 50% by day 21. (b) Statistical analysis with a Student t test. *p < 0.05; **p < 0.005.

Back to article page

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us