TY - JOUR AU - Reginster, J. Y. AU - Deroisy, R. AU - Rovati, L. C. AU - Lee, R. L. AU - Lejeune, E. AU - Bruyere, O. AU - Giacovelli, G. AU - Henrotin, Y. AU - Dacre, J. E. AU - Gosset, C. PY - 2001 DA - 2001// TI - Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial JO - Lancet VL - 357 UR - https://doi.org/10.1016/S0140-6736(00)03610-2 DO - 10.1016/S0140-6736(00)03610-2 ID - Reginster2001 ER - TY - JOUR AU - Pavelka, K. AU - Gatterova, J. AU - Olejarova, M. AU - Machacek, S. AU - Giacovelli, G. AU - Rovati, L. C. PY - 2002 DA - 2002// TI - Glucosamine sulphate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study JO - Arch Intern Med VL - 162 UR - https://doi.org/10.1001/archinte.162.18.2113 DO - 10.1001/archinte.162.18.2113 ID - Pavelka2002 ER - TY - JOUR AU - Bruyere, O. AU - Honore, A. AU - Ethgen, O. AU - Rovati, L. C. AU - Giacovelli, G. AU - Henrotin, Y. E. AU - Seidel, L. AU - Reginster, J. Y. PY - 2003 DA - 2003// TI - Correlation between radiographic severity of knee osteoarthritis and future disease progression. Results from a 3-year prospective, placebo-controlled study evaluating the effect of glucosamine sulfate JO - Osteoarthritis Cartilage VL - 11 UR - https://doi.org/10.1053/joca.2002.0848 DO - 10.1053/joca.2002.0848 ID - Bruyere2003 ER - TY - JOUR AU - Towheed, T. E. PY - 2003 DA - 2003// TI - Current status of glucosamine therapy in osteoarthritis JO - Arthritis Rheum VL - 49 UR - https://doi.org/10.1002/art.11183 DO - 10.1002/art.11183 ID - Towheed2003 ER - TY - JOUR AU - Muller-Fassbender, H. AU - Bach, G. L. AU - Haase, W. AU - Rovati, L. C. AU - Setnikar, I. PY - 1994 DA - 1994// TI - Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee JO - Osteoarthritis Cartilage VL - 2 UR - https://doi.org/10.1016/S1063-4584(05)80007-X DO - 10.1016/S1063-4584(05)80007-X ID - Muller-Fassbender1994 ER - TY - JOUR AU - Lopez Vaz, A. PY - 1982 DA - 1982// TI - Double-blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoarthrosis of the knee in out-patients JO - Curr Med Res Opin VL - 8 UR - https://doi.org/10.1185/03007998209112375 DO - 10.1185/03007998209112375 ID - Lopez Vaz1982 ER - TY - JOUR AU - Clegg, D. O. AU - Reda, D. J. AU - Harris, C. L. AU - Klein, M. A. AU - O'Dell, J. R. AU - Hooper, M. M. AU - Bradley, J. D. AU - Bingham, C. O. AU - Weisman, M. H. AU - Jackson, C. G. PY - 2006 DA - 2006// TI - Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis JO - N Engl J Med VL - 354 UR - https://doi.org/10.1056/NEJMoa052771 DO - 10.1056/NEJMoa052771 ID - Clegg2006 ER - TY - JOUR AU - Mengshol, J. A. AU - Vincenti, M. P. AU - Coon, C. I. AU - Barchowsky, A. AU - Brinckerhoff, C. E. PY - 2000 DA - 2000// TI - Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3 JO - Arthritis Rheum VL - 43 UR - https://doi.org/3.0.CO;2-4 DO - 3.0.CO;2-4 ID - Mengshol2000 ER - TY - JOUR AU - Westermarck, J. AU - Li, S. P. AU - Kallunki AU - Han, J. AU - Kahari, V. M. PY - 2001 DA - 2001// TI - p38 mitogen-activated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression JO - Mol Cell Biol VL - 21 UR - https://doi.org/10.1128/MCB.21.7.2373-2383.2001 DO - 10.1128/MCB.21.7.2373-2383.2001 ID - Westermarck2001 ER - TY - JOUR AU - Liacini, A. AU - Sylvester, J. AU - Li, W. Q. AU - Huang, W. AU - Dehnade, F. AU - Ahmad, M. AU - Zafarullah, M. PY - 2003 DA - 2003// TI - Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes JO - Exp Cell Res VL - 288 UR - https://doi.org/10.1016/S0014-4827(03)00180-0 DO - 10.1016/S0014-4827(03)00180-0 ID - Liacini2003 ER - TY - JOUR AU - Nagase, H. AU - Kashiwagi, M. PY - 2003 DA - 2003// TI - Aggrecanases and cartilage matrix degradation JO - Arthritis Res Ther VL - 5 UR - https://doi.org/10.1186/ar630 DO - 10.1186/ar630 ID - Nagase2003 ER - TY - JOUR AU - Burrage, P. S. AU - Mix, K. S. AU - Brinckerhoff, C. E. PY - 2006 DA - 2006// TI - Matrix metalloproteinases: role in arthritis JO - Front Biosci VL - 11 UR - https://doi.org/10.2741/1817 DO - 10.2741/1817 ID - Burrage2006 ER - TY - JOUR AU - Sandy, J. D. AU - Gamett, D. AU - Thompson, V. AU - Verscharen, C. PY - 1998 DA - 1998// TI - Chondrocyte-mediated catabolism of aggrecan: aggrecanase-dependent cleavage induced by interleukin-1 or retinoic acid can be inhibited by glucosamine JO - Biochem J VL - 335 UR - https://doi.org/10.1042/bj3350059 DO - 10.1042/bj3350059 ID - Sandy1998 ER - TY - JOUR AU - Fenton, J. I. AU - Chlebek-Brown, K. A. AU - Peters, T. L. AU - Caron, J. P. AU - Orth, M. W. PY - 2000 DA - 2000// TI - Glucosamine HCl reduces equine articular cartilage degradation in explant culture JO - Osteoarthritis Cartilage VL - 8 UR - https://doi.org/10.1053/joca.1999.0299 DO - 10.1053/joca.1999.0299 ID - Fenton2000 ER - TY - JOUR AU - Orth, M. W. AU - Peters, T. L. AU - Hawkins, J. N. PY - 2002 DA - 2002// TI - Inhibition of articular cartilage degradation by glucosamine-HCl and chondroitin sulphate JO - Equine Vet J VL - 34 UR - https://doi.org/10.1111/j.2042-3306.2002.tb05423.x DO - 10.1111/j.2042-3306.2002.tb05423.x ID - Orth2002 ER - TY - JOUR AU - Dodge, G. R. AU - Jimenez, S. A. PY - 2003 DA - 2003// TI - Glucosamine sulfate modulates the levels of aggrecan and matrix metalloproteinase-3 synthesized by cultured human osteoarthritis articular chondrocytes JO - Osteoarthritis Cartilage VL - 11 UR - https://doi.org/10.1016/S1063-4584(03)00052-9 DO - 10.1016/S1063-4584(03)00052-9 ID - Dodge2003 ER - TY - JOUR AU - Byron, C. R. AU - Orth, M. W. AU - Venta, P. J. AU - Lloyd, J. W. AU - Caron, J. P. PY - 2003 DA - 2003// TI - Influence of glucosamine on matrix metalloproteinase expression and activity in lipopolysaccharide-stimulated equine chondrocytes JO - Am J Vet Res VL - 64 UR - https://doi.org/10.2460/ajvr.2003.64.666 DO - 10.2460/ajvr.2003.64.666 ID - Byron2003 ER - TY - JOUR AU - Nakamura, H. AU - Shibakawa, A. AU - Tanaka, M. AU - Kato, T. AU - Nishioka, K. PY - 2004 DA - 2004// TI - Effects of glucosamine hydrochloride on the production of prostaglandin E2, nitric oxide and metalloproteases by chondrocytes and synoviocytes in osteoarthritis JO - Clin Exp Rheumatol VL - 22 ID - Nakamura2004 ER - TY - JOUR AU - Uitterlinden, E. J. AU - Jahr, H. AU - Koevoet, J. L. M. AU - Jenniskens, Y. M. AU - Bierma-Zeinstra, S. M. A. AU - DeGroot, J. AU - Verhaar, J. A. AU - Weinans, H. AU - van Osch, G. J. PY - 2006 DA - 2006// TI - Glucosamine decreases expression of anabolic and catabolic genes in human osteoarthritic cartilage explants JO - Osteoarthritis Cartilage VL - 14 UR - https://doi.org/10.1016/j.joca.2005.10.001 DO - 10.1016/j.joca.2005.10.001 ID - Uitterlinden2006 ER - TY - JOUR AU - Shikhman, A. R. AU - Kuhn, K. AU - Alaaeddine, N. AU - Lotz, M. PY - 2001 DA - 2001// TI - N-acetylglucosamine prevents IL-1 beta-mediated activation of human chondrocytes JO - J Immunol VL - 166 UR - https://doi.org/10.4049/jimmunol.166.8.5155 DO - 10.4049/jimmunol.166.8.5155 ID - Shikhman2001 ER - TY - JOUR AU - Gouze, J. N. AU - Bordji, K. AU - Gulberti, S. AU - Terlain, B. AU - Netter, P. AU - Magdalou, J. AU - Fournel-Gigleux, S. AU - Ouzzine, M. PY - 2001 DA - 2001// TI - Interleukin-1beta down-regulates the expression of glucuronosyltransferase I, a key enzyme priming glycosaminoglycan biosynthesis: influence of glucosamine on interleukin-1beta-mediated effects in rat chondrocytes JO - Arthritis Rheum VL - 44 UR - https://doi.org/3.0.CO;2-M DO - 3.0.CO;2-M ID - Gouze2001 ER - TY - JOUR AU - Largo, R. AU - Alvarez-Soria, M. A. AU - Diez-Ortego, I. AU - Calvo, E. AU - Sanchez-Pernaute, O. AU - Egido, J. AU - Herrero-Beaumont, G. PY - 2003 DA - 2003// TI - Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes JO - Osteoarthritis Cartilage VL - 11 UR - https://doi.org/10.1016/S1063-4584(03)00028-1 DO - 10.1016/S1063-4584(03)00028-1 ID - Largo2003 ER - TY - JOUR AU - Chan, P. S. AU - Caron, J. P. AU - Rosa, G. J. AU - Orth, M. W. PY - 2005 DA - 2005// TI - Glucosamine and chondroitin sulfate regulate gene expression and synthesis of nitric oxide and prostaglandin E(2) in articular cartilage explants JO - Osteoarthritis Cartilage VL - 13 UR - https://doi.org/10.1016/j.joca.2005.01.003 DO - 10.1016/j.joca.2005.01.003 ID - Chan2005 ER - TY - JOUR AU - Gouze, J. N. AU - Bianchi, A. AU - Becuwe, P. AU - Dauca, M. AU - Netter, P. AU - Magdalou, J. AU - Terlain, B. AU - Bordji, K. PY - 2002 DA - 2002// TI - Glucosamine modulates IL-1-induced activation of rat chondrocytes at a receptor level, and by inhibiting the NF-kappa B pathway JO - FEBS Lett VL - 510 UR - https://doi.org/10.1016/S0014-5793(01)03255-0 DO - 10.1016/S0014-5793(01)03255-0 ID - Gouze2002 ER - TY - JOUR AU - Grigolo, B. AU - Roseti, L. AU - Neri, S. AU - Gobbi, P. AU - Jensen, P. AU - Major, E. O. AU - Facchini, A. PY - 2002 DA - 2002// TI - Human articular chondrocytes immortalized by HPV-16 E6 and E7 genes: Maintenance of differentiated phenotype under defined culture conditions JO - Osteoarthritis Cartilage VL - 10 UR - https://doi.org/10.1053/joca.2002.0836 DO - 10.1053/joca.2002.0836 ID - Grigolo2002 ER - TY - JOUR AU - Scotto d'Abusco, A. AU - Cicione, C. AU - Calamia, V. AU - Negri, R. AU - Giordano, C. AU - Grigolo, B. AU - Politi, L. AU - Scandurra, R. PY - 2007 DA - 2007// TI - Glucosamine and its N-acetyl-phenylalanine derivative prevent TNF-alpha-induced transcriptional activation in human chondrocytes JO - Clin Exp Rheumatol VL - 25 ID - Scotto d'Abusco2007 ER - TY - JOUR AU - Roseti, L. AU - Facchini, A. AU - De Franceschi, L. AU - Marconi, E. AU - Major, E. O. AU - Grigolo, B. PY - 2007 DA - 2007// TI - Induction of original phenotype of human immortalized chondrocytes: a quantitative gene expression analysis JO - Int J Mol Med VL - 19 ID - Roseti2007 ER - TY - JOUR AU - Seger, R. AU - Krebs, E. G. PY - 1995 DA - 1995// TI - The MAPK signaling cascade JO - FASEB J VL - 9 ID - Seger1995 ER - TY - JOUR AU - English, J. AU - Pearson, G. AU - Wilsbacher, J. AU - Swantek, J. AU - Karandikar, M. AU - Xu, S. AU - Cobb, M. H. PY - 1999 DA - 1999// TI - New insights into the control of MAP kinase pathways JO - Exp Cell Res VL - 253 UR - https://doi.org/10.1006/excr.1999.4687 DO - 10.1006/excr.1999.4687 ID - English1999 ER - TY - JOUR AU - Firestein, G. S. AU - Manning, A. M. PY - 1999 DA - 1999// TI - Signal transduction and transcription factors in rheumatic disease JO - Arthritis Rheum VL - 42 UR - https://doi.org/3.0.CO;2-I DO - 3.0.CO;2-I ID - Firestein1999 ER - TY - JOUR AU - Ijiri, K. AU - Zerbini, L. F. AU - Peng, H. AU - Correa, R. G. AU - Lu, B. AU - Walsh, N. AU - Zhao, Y. AU - Taniguchi, N. AU - Huang, X. L. AU - Otu, H. PY - 2005 DA - 2005// TI - A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation JO - J Biol Chem VL - 280 UR - https://doi.org/10.1074/jbc.M504202200 DO - 10.1074/jbc.M504202200 ID - Ijiri2005 ER - TY - JOUR AU - Zachara, N. E. AU - Hart, G. W. PY - 2004 DA - 2004// TI - O-GlcNAc a sensor of cellular state: the role of nucleocytoplasmic glycosylation in modulating cellular function in response to nutrition and stress JO - Biochim Biophys Acta VL - 1673 UR - https://doi.org/10.1016/j.bbagen.2004.03.016 DO - 10.1016/j.bbagen.2004.03.016 ID - Zachara2004 ER - TY - JOUR AU - Zachara, N. E. AU - Hart, G. W. PY - 2006 DA - 2006// TI - Cell signaling, the essential role of O-GlcNAc! JO - Biochim Biophys Acta VL - 1761 UR - https://doi.org/10.1016/j.bbalip.2006.04.007 DO - 10.1016/j.bbalip.2006.04.007 ID - Zachara2006 ER - TY - JOUR AU - Chan, P. S. AU - Caron, J. P. AU - Orth, M. W. PY - 2005 DA - 2005// TI - Effect of glucosamine and chondroitin sulfate on regulation of gene expression of proteolytic enzymes and their inhibitors in interleukin-1-challenged bovine articular cartilage explants JO - Am J Vet Res VL - 66 UR - https://doi.org/10.2460/ajvr.2005.66.1870 DO - 10.2460/ajvr.2005.66.1870 ID - Chan2005 ER - TY - JOUR AU - Duerr, S. AU - Stremme, S. AU - Soeder, S. AU - Bau, B. AU - Aigner, T. PY - 2004 DA - 2004// TI - MMP-2/gelatinase A is a gene product of human adult articular chondrocytes and is increased in osteoarthritic cartilage JO - Clin Exp Rheumatol VL - 22 ID - Duerr2004 ER - TY - JOUR AU - Soder, S. AU - Roach, H. I. AU - Oehler, S. AU - Bau, B. AU - Haag, J. AU - Aigner, T. PY - 2006 DA - 2006// TI - MMP-9/gelatinase B is a gene product of human adult articular chondrocytes and increased in osteoarthritic cartilage JO - Clin Exp Rheumatol VL - 24 ID - Soder2006 ER - TY - JOUR AU - Uldry, M. AU - Ibberson, M. AU - Hosokawa, M. AU - Thorens, B. PY - 2002 DA - 2002// TI - GLUT2 is a high affinity glucosamine transporter JO - FEBS Lett VL - 524 UR - https://doi.org/10.1016/S0014-5793(02)03058-2 DO - 10.1016/S0014-5793(02)03058-2 ID - Uldry2002 ER - TY - JOUR AU - Windhaber, R. A. AU - Wilkins, R. J. AU - Meredith, D. PY - 2003 DA - 2003// TI - Functional characterisation of glucose transport in bovine articular chondrocytes JO - Pflugers Arch VL - 446 UR - https://doi.org/10.1007/s00424-003-1080-5 DO - 10.1007/s00424-003-1080-5 ID - Windhaber2003 ER - TY - JOUR AU - Ahmed, S. AU - Rahman, A. AU - Hasnain, A. AU - Goldberg, V. M. AU - Haqqi, T. M. PY - 2003 DA - 2003// TI - Phenyl N-tert-butylnitrone down-regulates interleukin-1 beta-stimulated matrix metalloproteinase-13 gene expression in human chondrocytes: suppression of c-Jun NH2-terminal kinase, p38-mitogen-activated protein kinase and activating protein-I JO - J Pharmacol Exp Ther VL - 305 UR - https://doi.org/10.1124/jpet.102.048611 DO - 10.1124/jpet.102.048611 ID - Ahmed2003 ER - TY - JOUR AU - Ho, L. J. AU - Lin, L. C. AU - Hung, L. F. AU - Wang, S. J. AU - Lee, C. H. AU - Chang, D. M. AU - Lai, J. H. AU - Tai, T. Y. PY - 2005 DA - 2005// TI - Retinoic acid blocks pro-inflammatory cytokine-induced matrix metalloproteinase production by down-regulating JNK-AP-1 signaling in human chondrocytes JO - Biochem Pharmacol VL - 70 UR - https://doi.org/10.1016/j.bcp.2005.04.039 DO - 10.1016/j.bcp.2005.04.039 ID - Ho2005 ER -