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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Src kinase inhibition promotes the chondrocyte phenotype

Figure 2

Src kinase activity regulates chondrocyte cell numbers. Primary mouse chondrocytes were incubated for 1 to 3 days with dimethyl sulphoxide (DMSO), (a) the general tyrosine kinase inhibitors Tyr A23, Tyr A25 and Tyr A47, or (b) the Src inhibitor PP2 (1 and 10 μmol/l each). Cell numbers were determined by MTT assay. All inhibitors reduced cell numbers at the 10 μmol/l concentration, but the effects of PP2 were more pronounced (n = 4; *P < 0.01, ***P < 0.001).

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