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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Src kinase inhibition promotes the chondrocyte phenotype

Figure 3

PP2 promotes expression of early chondrocyte marker genes. Primary mouse chondrocytes were incubated for 1 to 3 days with dimethyl sulphoxide (DMSO) or the Src inhibitor PP2 (10 ╬╝mol/l), and transcript levels of early chondrocyte marker genes were determined by real-time PCR. Expression levels of (a) Sox9, (b) Sox5, (c) Sox6, (d) Col2a1 and (e) Acan (aggrecan) were significantly increased upon Src inhibition (n = 3; **P < 0.01, ***P < 0.001).

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