Figure 5From: Src kinase inhibition promotes the chondrocyte phenotypePP2 promotes expression of late chondrocyte marker genes. Primary mouse chondrocytes were incubated for 1 to 3 days with dimethyl sulphoxide (DMSO) or the Src inhibitor PP2 (10 μmol/l), and transcript levels of late chondrocyte marker genes were determined by real-time PCR. Expression levels of (a) Col10a1, (b) Ihh, (c) Cdkn1c and (d) Atf3 were significantly increased upon Src inhibition (n = 3; *P < 0.05, **P < 0.01, ***P < 0.001).Back to article page