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Figure 7 | Arthritis Research & Therapy

Figure 7

From: Src kinase inhibition promotes the chondrocyte phenotype

Figure 7

PP2 promotes cell rounding and cortical actin formation. Primary mouse chondrocytes were incubated for 24 hours with (a) dimethyl sulphoxide or (b) the Src inhibitor PP2 (10 μmol/l), and cells were stained with rhodamine-phalloidin (red) for polymerized actin and with DAPI for nuclei (blue). PP2 induced cell rounding, loss of stress fibre, and cortical organization of actin (scale bar: 2 μm).

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