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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Differential responsiveness to immunoablative therapy in refractory rheumatoid arthritis is associated with level and avidity of anti-cyclic citrullinated protein autoantibodies: a case study

Figure 2

Associations between synovial inflammation and circulating ACPA-IgG autoantibodies. (a) Semiquantitative scores of individual patients before immunoablative therapy, scoring synovial infiltration for CD68 expression (macrophages), CD138 expression (plasma cells), CD20 expression, CD79a expression (B cells), CD3 expression (T-cells), Ki-67 expression (proliferation marker) and total inflammation. (b) Correlation of synovial inflammation scores with serum levels of antibodies against anti-cyclic citrullinated protein (ACPA)-IgG (open symbols) and avidity of ACPA-IgG (closed symbols) before immunoablative treatment. Each symbol corresponds to a distinct patient. (c) Correlation of serum levels of ACPA-IgG with C-reactive protein (CRP) levels (r = 0.56, P < 0.001) during complete follow up in the three patients whose ACPA-IgG levels are susceptible to immunoablative therapy ('ACPA responders'). (d) Correlation of serum levels of ACPA-IgG with CRP levels (r = 0.027, P = 0.86) during complete follow up in the three patients whose ACPA-IgG levels remained stable after immunoablative therapy ('ACPA nonresponders'). AU, arbitrary units; NaSCN, sodium thiocyanate.

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Arthritis Research & Therapy

ISSN: 1478-6362

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