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Table 2 Baseline measures of individual standardized cartilage biomarkers and their respective prediction of subsequent cartilage loss on magnetic resonance imaging

From: Cartilage markers and their association with cartilage loss on magnetic resonance imaging in knee osteoarthritis: the Boston Osteoarthritis Knee Study

  Unadjusted OR (95% CI) R 2 AUC P value Adjusted ORa (95% CI)
COMP 6.09 (1.34, 27.67) 0.06 0.60 0.02 6.35 (1.36–29.65)
846 epitope 0.93 (0.51, 1.71) 0.001 0.52 0.82 0.96 (0.52, 1.78)
CPII 1.19 (0.61, 2.32) 0.002 0.53 0.62 1.18 (0.60, 2.32)
C1,2C 0.69 (0.30, 1.59) 0.008 0.55 0.38 0.72 (0.31, 1.68)
Col2CTX/Cr ratio 0.99 (0.65, 1.52) 0.000 0.52 0.97 0.95 (0.61, 1.47)
C2C 0.39 (0.13, 1.13) 0.03 0.58 0.08 0.4 (0.14, 1.17)
  1. aAdjusted for age, gender, and body mass index. AUC, area under the curve; C2C, collagenase cleavage of triple-helical type II collagen; CI, confidence interval; Col2CTx, crosslinked peptides from the C-telopeptide domain of type II collagen; COMP, Cartilage Oligomeric Matrix Protein; CPII, C-propeptide of type II collagen; OR, odds ratio.