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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Importance of spliceosomal RNP1 motif for intermolecular T-B cell spreading and tolerance restoration in lupus

Figure 4

Effect of a brief peptide P140 therapy on the spontaneous T cell spreading in MRL/lpr mice. Mice were either treated with peptide P140 (hatched bars) administrated intravenously in saline at weeks 5, 7 and 9 or received saline alone (solid bars). The proliferative response of PBLs was measured ex vivo at 10 weeks in the presence of selected peptides (100 μM) containing (P140, 35–54 U1-A, RNP1-U1A, 35–55 hnRNP-A2, RNP1-A2) or not (183–202 of the U1-70K protein, 97–119 SmD1) an RNP1 motif. A mean SI > 2 was considered to be positive (horizontal line). The average tritiated thymidine incorporation in the absence of peptide and in the presence of Con-A was 50 and 2,000 cpm, respectively. Bars show the mean ± SEM. Significant differences are indicated. ns: non-significant reduction.

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