Figure 5

Brief peptide P140 therapy does not affect immune responses to viral challenge in MRL/lpr mice. P140-treated (closed symbols) and untreated MRL/lpr mice (open symbols) (10 mice/group) were challenged intra-nasally with infectious influenza virus. (a) Thirteen days after viral challenge, the proliferative response of PBLs to increasing concentrations of HA peptide 307–319 was measured ex vivo. Results are expressed as SI. Bars show the mean ± SEM. The average tritiated thymidine incorporation in the absence of peptide and in the presence of Con-A was 50 and 4,000 cpm, respectively. (b) Weight loss pattern after intra-nasal viral challenge. The weight of MRL/lpr mice treated or untreated with P140 peptide was compared.