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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Analysis of C4 and the C4 binding protein in the MRL/lpr mouse

Figure 4

Serum C3 and C4 levels in knockout MRL mice, control MRL mice, and nonautoimmune mice. (a) Serum C3 levels from 20-week-old C4bp-/-MRL/lpr (KO MRL) mice (n = 6) and littermate control (CTRL MRL) mice (n = 5) were measured by ELISA, and means values for 1:4,000 dilution are shown. P > 0.05 at all dilutions tested. OD450, optical density at 450 nm. (b) Serum C4 levels from 20-week-old KO MRL mice (n = 13) and CTRL MRL mice (n = 9) were compared with levels from mice at different ages as well as 20-week-old KO C57BL/6 (B6) mice, CTRL B6 mice, and C4-deficient B6 mice (n = 3 for each). Serum levels were measured by serial dilutions using sandwich ELISA, and mean values for 1:200 dilution are shown. *P < 0.001.

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