From: Analysis of C4 and the C4 binding protein in the MRL/lpr mouse
 | C4bp knockout MRL mice (n = 16) | Littermate control MRL mice (n = 13) |
---|---|---|
Proteinuria (mg/g/day) | 0.53 ± 0.08 | 0.48 ± 0.05 |
Serum creatinine (mg/dl) | 0.16 ± 0.03 | 0.20 ± 0.04 |
Hypercellularity | 1.9 ± 0.2 | 2.0 ± 0.3 |
Crescents (%) | 9 ± 4 | 11 ± 6 |
Sclerosis (%) | 17 ± 7 | 38 ± 9 |
Periglomerular leukocytes | 14 ± 3 | 15 ± 2 |
Tubulointerstitial disease | 1.4 ± 0.3 | 1.3 ± 0.3 |
Vasculitis | 1.3 ± 0.1* | 2.4 ± 0.2 |
IgG staining | 2.0 ± 0.2 | 2.0 ± 0.2 |
C3 staining | 1.5 ± 0.2 | 1.6 ± 0.3 |
C4 staining | 1.3 ± 0.2 | 1.3 ± 0.1 |
C1q staining | 0.6 ± 0.1 | 0.8 ± 0.1 |