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Table 2 Renal disease in C4bp knockout MRL mice compared with littermate control MRL mice

From: Analysis of C4 and the C4 binding protein in the MRL/lpr mouse

 

C4bp knockout MRL mice (n = 16)

Littermate control MRL mice (n = 13)

Proteinuria (mg/g/day)

0.53 ± 0.08

0.48 ± 0.05

Serum creatinine (mg/dl)

0.16 ± 0.03

0.20 ± 0.04

Hypercellularity

1.9 ± 0.2

2.0 ± 0.3

Crescents (%)

9 ± 4

11 ± 6

Sclerosis (%)

17 ± 7

38 ± 9

Periglomerular leukocytes

14 ± 3

15 ± 2

Tubulointerstitial disease

1.4 ± 0.3

1.3 ± 0.3

Vasculitis

1.3 ± 0.1*

2.4 ± 0.2

IgG staining

2.0 ± 0.2

2.0 ± 0.2

C3 staining

1.5 ± 0.2

1.6 ± 0.3

C4 staining

1.3 ± 0.2

1.3 ± 0.1

C1q staining

0.6 ± 0.1

0.8 ± 0.1

  1. *P < 0.0001.