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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study

Figure 1

Proteinase-activated receptor 2 (PAR-2) gene expression and protein synthesis. (a) mRNA levels, as determined by real-time quantitative polymerase chain reaction as described in Materials and methods, in normal (n = 4) and osteoarthritis (n = 6) chondrocytes. (b) PAR-2 immunostaining in normal (n = 4) and osteoarthritis (n = 4) cartilage. The percentage of positive chondrocytes represents the number of chondrocytes staining positive for PAR-2 of the total number of chondrocytes. Data are expressed as median and range and are presented as box plots, in which the boxes represent the first and third quartiles, the line within the box represents the median, and the lines outside the box represent the spread of values. P values indicate the comparison of normal to osteoarthritis cartilage using the Mann-Whitney U test. (c) Representative sections showing PAR-2 immunostaining in normal and osteoarthritis cartilage. The arrows refer to positive chondrocytes.

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