Table 1 Functions of Jun and Fos proteins
From: Activator protein 1 (Fos/Jun) functions in inflammatory bone and skin disease
| Activator protein 1 protein | Phenotype | Affected organs/cells |
|---|---|---|
| Transgenic | ||
| H2Kb-Jun | None | None |
| Ubiquitin C-JunBa | Increased bone mass | Not defined |
| CD4-JunB | Enhanced T helper cell 2 maturation | Thymus, CD4 thymocytes |
| Ubiquitin C-JunD | Peripheral T cells and B cells reduced | Lymphocytes |
| H2Kb-Fos | Osteosarcoma | Bone, osteoblasts |
| H2Kb-Fos/Rsk-2-/y | Reduced osteosarcoma | Bone, osteoblasts |
| H2Kb-FosB | None | Bone |
| TCRβ-ΔFosB | Impaired T cell differentiation | Thymus, immature thymocytes |
| NSE-ΔFosB | Osteosclerosis | Bone, osteoblasts |
| H2Kb-Fra-1 | Osteosclerosis | Bone, osteoblasts |
| CMV-Fra-2 | Occular malformations | Anterior eye structure |
| H2Kb-Fra-2a | Increased bone mass, fibrosis | Bone, internal organs, skin |
| Knockout | ||
| Jun | Embryonic lethal on embryonic day 12.5 | Liver, heart, neural crest |
| JunB | Embryonic lethal on embryonic day 10 | Extraembryonic tissues |
| JunD | Male sterility | Testis, spermatides |
| c-Fos | Osteopetrosis | Bone, osteoclasts |
| FosB | Nurturing defect | Brain, hypothalamus |
| Fra-1 | Embryonic lethal on embryonic day 9.5 | Extraembyonic tissue |
| Fra-2 | Lethal at birth | Bone, osteoclasts |
| Conditional | ||
| Alfp-cre Jun | Liver regeneration defect | Liver, hepatocytes |
| Col2a1-cre Jun | Scoliosis | Bone, notochordal cells |
| Nestin-cre Jun | Axonal regeneration defect | Central nervous system, motoneurons |
| MORE-cre JunB | Osteopenia | Bone, osteoclasts, osteoblasts |
| K5-cre Jun | Eyes open at birth, reduced skin tumors | Keratinocytes |
| Nestin-cre Fos | Learning defects | Brain, hippocampal neurons |
| MORE-cre Fra-1 | Osteopenia | Bone, osteoblasts |
| Inducible | ||
| K5-creERTJunB + Jun | Psoriasis-like disease | Skin, joints, keratinocytes |