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Figure 8 | Arthritis Research & Therapy

Figure 8

From: Methionine aminopeptidase-2 blockade reduces chronic collagen-induced arthritis: potential role for angiogenesis inhibition

Figure 8

PPI-2458 does not affect RA synovial cell inflammatory responses. Rheumatoid arthritis (RA) synovial cells were plated at 5 × 105 in 75 mm2 wells and incubated for 24 hours with either fumagillin (10 nmol/l), PPI-2458 (0.01 to 10 nmol/l), or 0.001% dimethyl sulfoxide as a vehicle control. Release of (a) vascular endothelial growth factor (VEGF), (b) IL-6, (c) transforming growth factor (TNF)-α and (d) monocyte chemoattractant protein (MCP)-1 were measured using enzyme-linked immunosorbent assay.

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