Table 1 Tumor necrosis factor (TNF) expression and effects of recombinant TNF administration or TNF blockade in murine models of systemic lupus erythematosus
From: The role of tumor necrosis factor-alpha in systemic lupus erythematosus
Model [Reference] | TNF expression | Effects of recombinant TNF | Effects of TNF blockade/deficiency |
|---|---|---|---|
NZB [12] | Normal | NA | Severe lupus in TNF-/- animals |
NZB/W [9,10] | Low | High dose: late onset (if given early), prolonged survival | NA |
[15] | High in nephritis | Low dose (late): increased renal inflammation | Â |
MRL/lpr [13,14] | High | NA | Improved arthritis, pneumonitis |
Moth-eaten [18] | High | NA | Improved skin, arthritis, pneumonitis |
C3H.SW [19] | High | NA | Less severe nephritis, leukocytopenia |