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Table 1 Tumor necrosis factor (TNF) expression and effects of recombinant TNF administration or TNF blockade in murine models of systemic lupus erythematosus

From: The role of tumor necrosis factor-alpha in systemic lupus erythematosus

Model [Reference] TNF expression Effects of recombinant TNF Effects of TNF blockade/deficiency
NZB [12] Normal NA Severe lupus in TNF-/- animals
NZB/W [9,10] Low High dose: late onset (if given early), prolonged survival NA
[15] High in nephritis Low dose (late): increased renal inflammation  
MRL/lpr [13,14] High NA Improved arthritis, pneumonitis
Moth-eaten [18] High NA Improved skin, arthritis, pneumonitis
C3H.SW [19] High NA Less severe nephritis, leukocytopenia
  1. NA, not assessed.