Characterization of celecoxib-induced cell death in rheumatoid arthritis fibroblast-like synoviocytes. Cells were treated at indicated concentrations and times with (a) celecoxib or (b) staurosporine or tumor necrosis factor-related apoptosis-inducing ligand. Apoptosis was evaluated by fluorescence-activated cell sorting analysis using Annexin V binding and TO-PRO-3 uptake. Representative data of three different experiments are shown. DMSO, dimethyl sulfoxide.