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Table 2 Associations between bone RANKL mRNA levels and serum RANKL levels and other listed parameters

From: Circulating RANKL is inversely related to RANKL mRNA levels in bone in osteoarthritic males

Parameter Males Females
  Versus RANKL mRNA (versus RANKL/OPG mRNA; r [P value]) Versus serum RANKL (r [P value]) Versus RANKL mRNA (r) Versus serum RANKL (r)
BV/TV -0.53 (0.052) 0.10 (0.745) -0.04 -0.20
BS/BV 0.57 (0.034) -0.30 (0.296) -0.12 -0.03
Tb.Th -0.67 (0.011) 0.34 (0.230) 0.09 -0.05
ES/BS (0.705 [0.003]) -0.35 (0.216) 0.33 -0.07
OS/BS (0.80 [0.0003]) -0.02 (0.935) 0.28 0.03
ALP (0.64 [0.011]) -0.49 (0.075) 0.07 0.08
OCN 0.71 (0.006) -0.31 (0.283) -0.02 -0.25
DPD (0.85 [<0.0001]) -0.08 (0.785) 0.23 -0.25
  1. Shown are correlations between receptor activator of nuclear factor-κB ligand (RANKL) mRNA levels (or RANKL mRNA/osteoprotegerin [OPG] mRNA) in bone and serum RANKL levels, and various structural parameters, static indices of bone turnover and biochemical bone turnover markers. ALP, alkaline phosphatase; BS/BV, specific surface of bone relative to bone tissue volume; BV/TV, bone volume fraction relative to bone tissue volume; DPD, deoxypyridinoline; ES/BS, eroded surface; OCN, osteocalcin; OS/BS, osteoid surface; Tb.Th, trabecular thickness.