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Table 3 Effect of PPAR-γ agonists on incidence of adjuvant arthritis

From: Anti-inflammatory effect of antidiabetic thiazolidinediones prevents bone resorption rather than cartilage changes in experimental polyarthritis

Group

Experiment

 

1

2

3

AIA

5/5

6/6

7/7

AIA + ROSI 3

5/6

-

-

AIA + ROSI 10

5/5

7/7

8/8

AIA + PIO 3

6/6

-

-

AIA + PIO 10

6/6

-

-

AIA + PIO 30

6/6

6/7

8/8

  1. PPAR, peroxisome proliferator-activated receptor; AIA, adjuvant-induced arthritis; ROSI, rosiglitazone 3 or 10 mg/kg/day; PIO, pioglitazone 3 or 10 or 30 mg/kg/day. Results are disease incidences at day 21.
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Arthritis Research & Therapy

ISSN: 1478-6362

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