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Table 5 Effect of PPAR-γ agonists on the histological grading of ankle synovium in arthritic rats.

From: Anti-inflammatory effect of antidiabetic thiazolidinediones prevents bone resorption rather than cartilage changes in experimental polyarthritis

Parameter Normal controls AIA controls AIA + ROSI 10 AIA + PIO 30
Synoviocyte hyperplasia 0 ± 0 3.93 ± 0.12* 2.00 ± 0.42# 0.80 ± 0.19#
Focal aggregates of lymphocytes 0.08 ± 0.14 3.50 ± 0.24* 1.60 ± 0.23# 1.20 ± 0.19#
Fibrosis 0.37 ± 0.26 3.73 ± 0.20* 2.60 ± 0.31# 1.00 ± 0.30#
Proliferating blood vessels (original magnification × 40) 0.37 ± 0.26 1.50 ± 0.24* 0.80 ± 0.35 1.07 ± 0.12
Perivascular infiltrates of lymphocytes 0.62 ± 0.26 1.60 ± 0.31* 0.80 ± 0.35 1.10 ± 0.25
Diffuse infiltrates of lymphocytes 0 ± 0 3.13 ± 0.16* 2.10 ± 0.25# 0.70 ± 0.22#
  1. PPAR, peroxisome proliferator-activated receptor; ROSI 10, rosiglitazone 10 mg/kg/day; PIO 30, pioglitazone 30 mg/kg/day; AIA, adjuvant-induced arthritis. Data are expressed as means ± SEM (n = 5 representative animals per group).
  2. *, P < 0.05 compared with normal controls; #, P < 0.05 compared with AIA controls (Mann–Whitney U test).