Skip to main content

Table 6 Effect of PPAR-γ agonists on biochemical markers of bone turnover in rats with adjuvant arthritis

From: Anti-inflammatory effect of antidiabetic thiazolidinediones prevents bone resorption rather than cartilage changes in experimental polyarthritis

Group Change in plasma osteocalcina (ng/ml) Change in urinary deoxypyridinolineb (nmol/mmol creatinine)
Normal controls -39 ± 11 -3 ± 6
AIA controls -50 ± 9 24 ± 7*
AIA + ROSI 10 -37 ± 12 9 ± 4
AIA + PIO 30 -32 ± 16 12 ± 5
  1. PPAR, peroxisome proliferator-activated receptor; AIA, adjuvant-induced arthritis; ROSI 10, rosiglitazone 10 mg/kg/day; PIO 30, pioglitazone 30 mg/kg/day. Data are expressed as means ± SEM (n = 5 for deoxypyridinoline; n = 6 for osteocalcin).
  2. *, P < 0.05 compared with normal controls (ANOVA and Fisher's PLSD test). aDay 21 minus day -1; bday 21 minus day 0.