From: Anti-inflammatory effect of antidiabetic thiazolidinediones prevents bone resorption rather than cartilage changes in experimental polyarthritis
Group
Change in plasma osteocalcina (ng/ml)
Change in urinary deoxypyridinolineb (nmol/mmol creatinine)
Normal controls
-39 ± 11
-3 ± 6
AIA controls
-50 ± 9
24 ± 7*
AIA + ROSI 10
-37 ± 12
9 ± 4
AIA + PIO 30
-32 ± 16
12 ± 5