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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Inhibition of hyaluronan export reduces collagen degradation in interleukin-1 treated cartilage

Figure 1

Inhibition of hyaluronan export in bovine chondrocytes. (a) Cartilage explants were incubated in the absence and presence of IL-1α and the drugs tadalafil (), zaprinast (□), or vardenafil (). The concentration of hyaluronan was determined in the supernatant after 3 days. The error bars indicate the standard deviation of three determinations. (b) Effect of inhibitors on hyaluronan synthase activity. A particulate fraction of chondrocytes was prepared and incubated with the substrates UDP-GlcNac and UDP-[14C]GlcA and increasing concentrations of tadalafil (), zaprinast (□), or vardenafil (), and the incorporation into [14C]hyaluronan was determined.

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