From: Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitrostudy
Functional annotation: gene title (gene symbol) | Accession no. | Chondrocyte mean fold change in expression (GCOS analysis) | Chondrocyte mean signal intensity (GCOS analysis) | ||
---|---|---|---|---|---|
 |  | RASFsn versus NDSFsn stimulation | RASFsn stimulation | NDSFsn stimulation | No stimulation |
Inflammatory/catabolic mediators | Â | Â | Â | Â | Â |
   Catalase (CAT) | NM_001752.1 | -1.7 | 672.85 | 1,221.90 | 1,386.65 |
   Chemokine (C-C motif) ligand 5 (RANTES) | NM_002985.1 | 4.1 | 103.40 | 25.20 | 18.95 |
   Chemokine orphan receptor 1 (CMKOR1) | AI817041 | 2.2 | 609.45 | 322.55 | 89.50 |
   Glutathione peroxidase 3 (GPX3) | AW149846 | -1.5 | 1,083.25 | 1,617.75 | 669.90 |
   Interleukin-1β (IL-1β) | M15330 | 2.2 | 91.80 | 34.10 | 36.45 |
   Interleukin-6 (IL-6) | NM_000600.1 | 2.6 | 10,058.00 | 4,907.15 | 56.25 |
   Nuclear factor-κB associated gene (NF-κB1) | NM_003998.1 | 1.5 | 472.80 | 312.10 | 176.75 |
   Nuclear factor-κB associated gene (NF-κB2) | BC002844.1 | 2.3 | 125.75 | 48.25 | 41.50 |
   Prostaglandin E synthase (PGES) | NM_004878.1 | 1.9 | 1,308.70 | 596.10 | 123.10 |
   TNF-α-inducible protein 2 (TNFAIP2) | NM_006291.1 | 2.6 | 337.65 | 109.90 | 98.90 |
   Tumor necrosis factor receptor (TNFRSF1B) | NM_001066.1 | 2.3 | 439.20 | 197.70 | 67.10 |
ECM degradation | Â | Â | Â | Â | Â |
   Matrix metalloproteinase 10 (MMP10) | NM_002425.1 | 2.7 | 587.60 | 233.90 | 20.05 |
   Matrix metalloproteinase 12 (MMP12) | NM_002426.1 | 5.2 | 161.40 | 25.90 | 18.00 |
ECM formation | Â | Â | Â | Â | Â |
   Collagen, type I, α1 (COL1A1) | NM_000088.1 | -2.3 | 472.15 | 1,182.40 | 6,603.50 |
   Collagen, type V, α1 (COL5A1) | N30339 | -1.9 | 143.80 | 296.95 | 862.60 |
   Collagen, type X, α1 (COL10A1) | X98568 | -4.6 | 36.50 | 163.90 | 5.00 |
   Collagen type XI, α1 (COL11A1) | J04177 | -1.7 | 565.80 | 982.25 | 1,146.10 |
   Testican-1 | NM_004598 | -1.8 | 543.80 | 1,384.10 | 2,311.00 |