Figure 3From: Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritisHistological evaluation of damage to murine knees. Histological sections of knee samples from murine collagen-induced arthritis study 1 were graded as described in Table 1. CP-690550 produced a dose-dependent inhibition of knee damage that reached statistical significance (p < 0.0001) at the 15 mg/kg/day dose relative to vehicle.Back to article page