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Table 3 CP-690550 serum levels (ng/ml)

From: Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis

Dose (mg/kg/d) Mouse study 1a Mouse study 2b Rat study
15 70 ± 17 37 ± 5 259 ± 41
5 27 ± 6 17 ± 2 124 ± 16
1.5 6 ± 1 < LLOQ 24 ± 5
  1. Data are mean ± standard error of the mean. All samples were collected at the termination of the study. n = 10 for all groups. LLOQ, lower limit of quantification.
  2. aLLOQ = 5 ng/ml (Pfizer study).
  3. bLLOQ = 10 ng/ml (Boulder BioPath study).