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Table 3 CP-690550 serum levels (ng/ml)

From: Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis

Dose (mg/kg/d)

Mouse study 1a

Mouse study 2b

Rat study

15

70 ± 17

37 ± 5

259 ± 41

5

27 ± 6

17 ± 2

124 ± 16

1.5

6 ± 1

< LLOQ

24 ± 5

  1. Data are mean ± standard error of the mean. All samples were collected at the termination of the study. n = 10 for all groups. LLOQ, lower limit of quantification.
  2. aLLOQ = 5 ng/ml (Pfizer study).
  3. bLLOQ = 10 ng/ml (Boulder BioPath study).
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Arthritis Research & Therapy

ISSN: 1478-6362

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