Information source | Relative risk compared with non-use of coxib or NSAID | |||||
---|---|---|---|---|---|---|
 | Ibuprofen | Naproxen | Diclofenac | All NSAIDs | Celecoxib | Rofecoxib |
Upper GI bleed [6] | 1.9 (1.6–2.2) | 4.0 (3.5–4.6) | 3.3 (2.8–3.9) | 4.2 (3.9–4.6) |  |  |
Upper GI bleed [5] | 1.7 (1.1–2.5) | 9.1 (6.0–14) | 4.9 (3.3–7.1) |  |  |  |
Hospital admission [7] |  |  |  | 4.0 (2.3–6.9) | 1.0 (0.7–1.6) | 1.9 (1.3–2.8) |
Upper GI bleed [70] |  |  |  | 3.3 (2.4–4.4) | 1.3 (0.7–2.8) | 2.1 (1.2–3.5) |
Upper GI bleed [71] | 4.1 (3.1–5.3) | 7.3 (4.7–11.4) | 3.1 (2.3–4.2) | 5.3 (4.5–6.2) | 1.0 (0.4–2.1) | 2.1 (1.1–4.0) |
CV events [4] | 1.07 (1.02–1.12) | 0.98 (0.92–1.05) | 1.44 (1.32–1.56) | 1.09 (1.06–1.13) | 0.96 (0.90–1.02) | 1.26 (1.17–1.36) |
CV events [8] | 1.07 (0.97–1.18) | 0.97 (0.87–1.07) | 1.40 (1.16–1.70) | 1.10 (1.00–1.21) | 1.06 (0.91–1.23) | 1.35 (1.15–1.59) |