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Table 3 Frequency of the IL-6 (G-174C, G-572C, G-597A) genotypes, by DIP OA status

From: Common interleukin-6promoter variants associate with the more severe forms of distal interphalangeal osteoarthritis

Genotype

Symptomatic DIP OA

P c

 

Condition absent (n = 485)

Condition present (n = 47–48)

 
 

n

Percentage

n

Percentage

 

IL-6(G-174C)a

    

0.016

   GG

93

19.2

13

27.1

 

   GC

235

48.5

29

60.4

 

   CC

157

32.4

6

12.5

 

   G allele carriage

328

67.6

42

87.5

0.004

   G allele frequency

421

43.4

55

57.3

0.010d

IL-6(G-572C)b

    

0.362

   GG

451

93.0

42

89.4

 

   GC

34

7.0

5

10.6

 

   C allele carriage

34

7.0

5

10.6

0.362

   C allele frequency

34

3.5

5

5.3

0.382

IL-6(G-597A)a

    

0.023

   GG

103

21.2

14

29.8

 

   GA

226

47.0

27

57.4

 

   AA

154

31.8

6

12.8

 

   G allele carriage

331

68.2

41

87.2

0.007

   G allele frequency

432

44.5

55

58.5

0.012e

  1. DIP OA, distal interphalangeal osteoarthritis. Symptomatic DIP OA was defined by the presence of both radiographic findings of grade 2 or more and symptoms in at least two DIP joints.
  2. aGenotypes were available for 533 subjects; bGenotypes were available for 532 subjects. cP value is given for the comparison between DIP OA status groups (Chi-square test or Fisher's exact probability test); dPcorr = 0.02, odds ratio 1.75 (95% confidence interval 1.15 to 2.67); ePcorr = 0.024, odds ratio 1.76 (95% confidence interval 1.15 to 2.69).
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Arthritis Research & Therapy

ISSN: 1478-6362

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