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Table 3 Frequency of the IL-6 (G-174C, G-572C, G-597A) genotypes, by DIP OA status

From: Common interleukin-6promoter variants associate with the more severe forms of distal interphalangeal osteoarthritis

Genotype Symptomatic DIP OA P c
  Condition absent (n = 485) Condition present (n = 47–48)  
  n Percentage n Percentage  
IL-6(G-174C)a      0.016
   GG 93 19.2 13 27.1  
   GC 235 48.5 29 60.4  
   CC 157 32.4 6 12.5  
   G allele carriage 328 67.6 42 87.5 0.004
   G allele frequency 421 43.4 55 57.3 0.010d
IL-6(G-572C)b      0.362
   GG 451 93.0 42 89.4  
   GC 34 7.0 5 10.6  
   C allele carriage 34 7.0 5 10.6 0.362
   C allele frequency 34 3.5 5 5.3 0.382
IL-6(G-597A)a      0.023
   GG 103 21.2 14 29.8  
   GA 226 47.0 27 57.4  
   AA 154 31.8 6 12.8  
   G allele carriage 331 68.2 41 87.2 0.007
   G allele frequency 432 44.5 55 58.5 0.012e
  1. DIP OA, distal interphalangeal osteoarthritis. Symptomatic DIP OA was defined by the presence of both radiographic findings of grade 2 or more and symptoms in at least two DIP joints.
  2. aGenotypes were available for 533 subjects; bGenotypes were available for 532 subjects. cP value is given for the comparison between DIP OA status groups (Chi-square test or Fisher's exact probability test); dPcorr = 0.02, odds ratio 1.75 (95% confidence interval 1.15 to 2.67); ePcorr = 0.024, odds ratio 1.76 (95% confidence interval 1.15 to 2.69).