|
Condition
|
Diplotypes
|
Condition absent
|
Condition present
|
Odds ratio (95% confidence interval)
|
|---|
| | |
n
|
Percentage
|
n
|
Percentage
|
Crude
|
Adjusted
|
|---|
|
DIP OA
| | | | | | | |
|
Total n
| |
309
| |
224
| | | |
| |
other/other
|
117
|
37.9
|
74
|
33.0
|
1.00
|
1.00
|
| |
G-G-G/other
|
148
|
47.9
|
107
|
47.8
|
1.14 (0.78–1.68)
|
1.17 (0.77–1.76)
|
| |
G-G-G/G-G-G
|
44
|
14.2
|
43
|
19.2
|
1.54 (0.93–2.58)
|
1.48 (0.86–2.55)
|
| |
G-G-G carriage
|
192
|
62.1
|
150
|
67.0
|
1.23 (0.86–1.77)
|
1.24 (0.85–1.83)
|
| |
G-G-G frequency
|
236
|
38.2
|
193
|
43.1
|
1.22 (0.96–1.57)
|
1.20 (0.92–1.56)
|
|
Symmetrical DIP OA
| | | | | | | |
|
Total n
| |
329
| |
205
| | | |
| |
other/other
|
127
|
38.6
|
64
|
31.2
|
1.00
|
1.00
|
| |
G-G-G/other
|
155
|
47.1
|
101
|
49.3
|
1.29 (0.87–1.91)
|
1.35 (0.89–2.04)
|
| |
G-G-G/G-G-G
|
47
|
14.3
|
40
|
19.5
|
1.69 (1.01–2.83)
|
1.65 (0.95–2.84)
|
| |
G-G-G carriage
|
202
|
61.4
|
141
|
68.8
|
1.38 (0.96–2.00)
|
1.42 (0.96–2.10)
|
| |
G-G-G frequency
|
229
|
35.9
|
181
|
42.1
|
1.30 (1.01–1.67)a
|
1.29 (0.99–1.68)
|
|
Symptomatic DIP OA
| | | | | | | |
|
Total n
| |
487
| |
48
| | | |
| |
other/other
|
185
|
38.0
|
6
|
35.7
|
1.00
|
1.00
|
| |
G-G-G/other
|
223
|
45.8
|
34
|
70.8
|
4.70 (1.93–11.44)a
|
5.03 (2.02–12.51)a
|
| |
G-G-G/G-G-G
|
79
|
16.2
|
8
|
16.7
|
3.12 (1.05–9.29)
|
3.01 (0.98–9.22)
|
| |
G-G-G carriage
|
302
|
62.0
|
42
|
87.5
|
4.29 (1.79–10.28)a
|
4.45 (1.82–10.88)a
|
| |
G-G-G frequency
|
381
|
39.1
|
50
|
51.0
|
1.83 (1.19–2.81)a
|
1.62 (1.07–2.45)a
|
- Distal interphalangeal osteoarthritis (DIP OA) was defined by the presence of radiographic findings of grade 2 or more in at least two DIP joints. Symmetrical DIP OA was defined by the presence of radiographic findings of grade 2 or more in at least one symmetrical pair of the DIP joints. Symptomatic DIP OA was defined by the presence of both radiographic findings of grade 2 or more and symptoms in at least two DIP joints.
- aP value remained statistically significant after correcting for multiple testing.
