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Table 4 Frequency of the IL-6 G-G-G diplotypes, by the DIP OA status (n = 533 to 535)

From: Common interleukin-6promoter variants associate with the more severe forms of distal interphalangeal osteoarthritis

Condition Diplotypes Condition absent Condition present Odds ratio (95% confidence interval)
   n Percentage n Percentage Crude Adjusted
DIP OA        
   Total n   309   224    
  other/other 117 37.9 74 33.0 1.00 1.00
  G-G-G/other 148 47.9 107 47.8 1.14 (0.78–1.68) 1.17 (0.77–1.76)
  G-G-G/G-G-G 44 14.2 43 19.2 1.54 (0.93–2.58) 1.48 (0.86–2.55)
  G-G-G carriage 192 62.1 150 67.0 1.23 (0.86–1.77) 1.24 (0.85–1.83)
  G-G-G frequency 236 38.2 193 43.1 1.22 (0.96–1.57) 1.20 (0.92–1.56)
Symmetrical DIP OA        
   Total n   329   205    
  other/other 127 38.6 64 31.2 1.00 1.00
  G-G-G/other 155 47.1 101 49.3 1.29 (0.87–1.91) 1.35 (0.89–2.04)
  G-G-G/G-G-G 47 14.3 40 19.5 1.69 (1.01–2.83) 1.65 (0.95–2.84)
  G-G-G carriage 202 61.4 141 68.8 1.38 (0.96–2.00) 1.42 (0.96–2.10)
  G-G-G frequency 229 35.9 181 42.1 1.30 (1.01–1.67)a 1.29 (0.99–1.68)
Symptomatic DIP OA        
   Total n   487   48    
  other/other 185 38.0 6 35.7 1.00 1.00
  G-G-G/other 223 45.8 34 70.8 4.70 (1.93–11.44)a 5.03 (2.02–12.51)a
  G-G-G/G-G-G 79 16.2 8 16.7 3.12 (1.05–9.29) 3.01 (0.98–9.22)
  G-G-G carriage 302 62.0 42 87.5 4.29 (1.79–10.28)a 4.45 (1.82–10.88)a
  G-G-G frequency 381 39.1 50 51.0 1.83 (1.19–2.81)a 1.62 (1.07–2.45)a
  1. Distal interphalangeal osteoarthritis (DIP OA) was defined by the presence of radiographic findings of grade 2 or more in at least two DIP joints. Symmetrical DIP OA was defined by the presence of radiographic findings of grade 2 or more in at least one symmetrical pair of the DIP joints. Symptomatic DIP OA was defined by the presence of both radiographic findings of grade 2 or more and symptoms in at least two DIP joints.
  2. aP value remained statistically significant after correcting for multiple testing.
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