|
Condition
|
Diplotypes
|
Condition absent
|
Condition present
|
Odds ratio (95% confidence interval)
|
|---|
| | |
n
|
Percentage
|
n
|
Percentage
|
Crude
|
Adjusted
|
|---|
|
DIP OA
| | | | | | | |
|
Total n
| |
306
| |
222
| | | |
| |
other/other
|
105
|
34.3
|
64
|
28.8
|
1.00
|
1.00
|
| |
G-G/other
|
147
|
48.0
|
109
|
49.1
|
1.22 (0.82–1.81)
|
1.27 (0.83–1.95)
|
| |
G-G/G-G
|
54
|
17.6
|
49
|
22.1
|
1.49 (0.91–2.44)
|
1.42 (0.84–2.41)
|
| |
G-G carriage
|
192
|
62.1
|
150
|
67.0
|
1.29 (0.89–1.87)
|
1.31 (0.88–1.96)
|
| |
G-G frequency
|
237
|
39.9
|
207
|
44.8
|
1.22 (0.96–1.56)
|
1.19 (0.92–1.55)
|
|
Symmetrical DIP OA
| | | | | | | |
|
Total n
| |
325
| |
204
| | | |
| |
other/other
|
114
|
35.1
|
55
|
27.0
|
1.00
|
1.00
|
| |
G-G/other
|
155
|
47.7
|
102
|
50.0
|
1.36 (0.91–2.05)
|
1.45 (0.94–2.23)
|
| |
G-G/G-G
|
56
|
17.2
|
47
|
23.0
|
1.74 (1.05–2.88)
|
1.69 (0.99–2.87)
|
| |
G-G carriage
|
302
|
62.0
|
42
|
87.5
|
1.46 (1.00–2.15)
|
1.52 (1.01–2.28)
|
| |
G-G frequency
|
267
|
41.1
|
196
|
48.0
|
1.33 (1.03–1.70)
|
1.31 (1.01–1.71)
|
|
Symptomatic DIP OA
| | | | | | | |
|
Total n
| |
483
| |
47
| | | |
| |
other/other
|
163
|
33.7
|
6
|
12.8
|
1.00
|
1.00
|
| |
G-G/other
|
230
|
47.6
|
28
|
59.6
|
3.31 (1.34–8.17)a
|
3.62 (1.43–9.15)a
|
| |
G-G/G-G
|
90
|
18.8
|
13
|
27.7
|
3.92 (1.44–10.68)a
|
3.79 (1.35–10.61)a
|
| |
G-G carriage
|
302
|
62.0
|
42
|
87.5
|
3.48 (1.45–8.37)a
|
3.67 (1.50–9.00)a
|
| |
G-G frequency
|
410
|
42.4
|
54
|
57.4
|
1.83 (1.19–2.81)a
|
1.62 (1.07–2.45)
|
- Distal interphalangeal osteoarthritis (DIP OA) was defined by the presence of radiographic findings of grade 2 or more in at least two DIP joints. Symmetrical DIP OA was defined by the presence of radiographic findings of grade 2 or more in at least one symmetrical pair of the DIP joints. Symptomatic DIP OA was defined by the presence of both radiographic findings of grade 2 or more and symptoms in at least two DIP joints.
- aP value remained statistically significant after correcting for multiple testing.
