Skip to main content

Table 5 Frequency of IL-6 G-G diplotypes (G-597A; G-174C) by DIP OA status (n = 528 to 530)

From: Common interleukin-6promoter variants associate with the more severe forms of distal interphalangeal osteoarthritis

Condition Diplotypes Condition absent Condition present Odds ratio (95% confidence interval)
   n Percentage n Percentage Crude Adjusted
DIP OA        
   Total n   306   222    
  other/other 105 34.3 64 28.8 1.00 1.00
  G-G/other 147 48.0 109 49.1 1.22 (0.82–1.81) 1.27 (0.83–1.95)
  G-G/G-G 54 17.6 49 22.1 1.49 (0.91–2.44) 1.42 (0.84–2.41)
  G-G carriage 192 62.1 150 67.0 1.29 (0.89–1.87) 1.31 (0.88–1.96)
  G-G frequency 237 39.9 207 44.8 1.22 (0.96–1.56) 1.19 (0.92–1.55)
Symmetrical DIP OA        
   Total n   325   204    
  other/other 114 35.1 55 27.0 1.00 1.00
  G-G/other 155 47.7 102 50.0 1.36 (0.91–2.05) 1.45 (0.94–2.23)
  G-G/G-G 56 17.2 47 23.0 1.74 (1.05–2.88) 1.69 (0.99–2.87)
  G-G carriage 302 62.0 42 87.5 1.46 (1.00–2.15) 1.52 (1.01–2.28)
  G-G frequency 267 41.1 196 48.0 1.33 (1.03–1.70) 1.31 (1.01–1.71)
Symptomatic DIP OA        
   Total n   483   47    
  other/other 163 33.7 6 12.8 1.00 1.00
  G-G/other 230 47.6 28 59.6 3.31 (1.34–8.17)a 3.62 (1.43–9.15)a
  G-G/G-G 90 18.8 13 27.7 3.92 (1.44–10.68)a 3.79 (1.35–10.61)a
  G-G carriage 302 62.0 42 87.5 3.48 (1.45–8.37)a 3.67 (1.50–9.00)a
  G-G frequency 410 42.4 54 57.4 1.83 (1.19–2.81)a 1.62 (1.07–2.45)
  1. Distal interphalangeal osteoarthritis (DIP OA) was defined by the presence of radiographic findings of grade 2 or more in at least two DIP joints. Symmetrical DIP OA was defined by the presence of radiographic findings of grade 2 or more in at least one symmetrical pair of the DIP joints. Symptomatic DIP OA was defined by the presence of both radiographic findings of grade 2 or more and symptoms in at least two DIP joints.
  2. aP value remained statistically significant after correcting for multiple testing.