Biomarker profiles in serum and saliva of experimental Sjögren's syndrome: associations with specific autoimmune manifestations

Table 1 Significantly different biomarker concentrations in NOD and Balb/c mice

Serum	Fold change	t-test P value	Saliva	Fold change	t-test P value
MIP-2 (CXCL-2)	0.74	0.0130	GCP-2 (CXCL-5)	1.81	< 0.0001
IP-10 (CXCL-10)	1.70	0.0145	MIP-2 (CXCL-2)	1.83	0.0236
LTN (XCL-1)	1.40	0.0037	IP-10 (CXCL-10)	4.58	0.0001
MCP-1 (CCL-2)	1.73	0.0007	LTN (XCL-1)	2.21	0.0204
MCP-3 (CCL-7)	1.99	0.0006	MCP-1 (CCL-2)	3.95	0.0304
MIP-1α (CCL-3)	1.37	0.0059	MCP-3 (CCL-7)	2.97	0.0024
MIP-1γ (CCL-9)	1.43	< 0.0001	MIP-1β (CCL-4)	3.14	0.0155
MDC (CCL-22)	1.28	0.0002	RANTES (CCL-5)	4.32	< 0.0001
MIP-3β (CCL-19)	1.57	0.0004	Eotaxin (CCL-11)	2.80	0.0179
OPN (SPP-1)	2.32	< 0.0001	MDC (CCL-22)	2.65	0.0102
IL-10	1.17	0.0201	IL-17	2.27	0.0294
CD40L	0.61	0.0136	GM-CSF (CSF-2)	2.06	0.0377
CD40	1.59	0.0007	IL-7	2.52	0.0244
IL-1α	0.67	0.0003	IL-10	1.36	0.0351
IL-18	1.58	0.0005	CD40	6.31	0.0277
EGF	1.44	0.0111	IL-11	12.18	0.0018
Growth hormone	3.41	0.0001	LIF	2.99	0.0116
SCF (Kitl)	1.29	0.0092	OSM	3.99	0.0102
VEGF-A	0.64	0.0051	IL-18	2.62	0.0193
Endothelin-1	1.64	0.0184	FGF-9 (ng/ml)	2.82	0.0021
Insulin	1.48	< 0.0001	M-CSF (CSF-1)	1.68	0.0289
CRP	1.85	< 0.0001	SCF (Kitl)	2.27	0.0349
Haptoglobin	1.14	0.0359	TPO	5.40	0.0003
SAP	1.43	< 0.0001	Leptin	-	0.0374
SGOT	1.33	0.0062	VCAM-1	1.49	0.0424
Factor III	1.45	0.0173	MMP-9	1.72	0.0191
Factor VII	1.54	0.0092	TIMP-1	1.58	0.0444
Fibrinogen	11.88	< 0.0001	MPO	1.97	0.0100
VCAM-1	1.39	< 0.0001	Anti-Insulin	1.32	0.0415
MMP-9	0.60	0.0170	SSB (anti-La)	1.20	0.0155
Cystatin-C	1.56	< 0.0001	Anti-RNP	1.46	0.0174
MPO	1.67	0.0001	Anti-beta 2GPI	1.56	0.0117
Apo A1	1.20	0.0024	Anti-mitochondrial	1.72	0.0392
IgA	0.47	< 0.0001	Anti-SCL70	1.40	0.0021
Anti-M3R IgG₁	18.56	0.0029
Anti-M3R IgG_2b	11.23	0.0019
Anti-M3R IgG_2c	77.28	< 0.0001
Anti-M3R IgG₃	2.14	0.0219

Fold change in biomarker concentrations between nonobese diabetic (NOD) and Balb/c mice. Proteins significantly different between the two strains (P < 0.05) are listed. For the remaining proteins, please refer to Additional file 1 (Supplementary table 2). Abbreviations not defined in the text: Apo, apolipoprotein; beta 2GPI, β₂-glycoprotein; EGF, epidermal growth factor; FGF, fibroblast growth factor; GM-CSF, granulocyte macrophage colony-stimulating factor; Kitl, Kit ligand; LIF, leukaemia inhibitory factor; LTN, lymphotactin; M-CSF, macrophage colony-stimulating factor; MPO, myeloperoxidase; OPN, osteopontin; OSM, oncostatin M; SAP, serum amyloid P; SCF, stem cell factor; SCL, scleroderoderma; TPO, thrombopoietin; VEGF, vascular endothelial cell growth factor.

ISSN: 1478-6362