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Table 2 Carrier frequency comparisons of the different HLA-DRB1 allele groups between rheumatoid arthritis cases and controls in Caucasoid and non-Caucasoid population samples

From: New classification of HLA-DRB1alleles in rheumatoid arthritis susceptibility: a combined analysis of worldwide samples

  RA cases, n (%) Controls, n (%) OR (95% CI)
S1 alleles    
   Caucasoids 125 (29.4%) 183 (41.3%) 0.59 (0.45–0.79)
   Non-Caucasoids 87 (26%) 140 (40%) 0.52 (0.37–0.71)
S2 alleles    
   Caucasoids 133 (31%) 66 (15%) 2.61 (1.87–3.64)
   Non-Caucasoids 48 (14%) 37 (11%) 1.40 (0.88–2.21)
S3D alleles    
   Caucasoids 123 (29%) 159 (36%) 0.73 (0.55–0.97)
   Non-Caucasoids 112 (33%) 120 (35%) 0.95 (0.69–1.30)
S3P alleles    
   Caucasoids 159 (37.5%) 108 (24%) 1.86 (1.39–2.49)
   Non-Caucasoids 170 (51%) 90 (26%) 2.93 (2.12–4.04)
X alleles    
   Caucasoids 201 (47%) 244 (55%) 0.74 (0.56–0.96)
   Non-Caucasoids 145 (43%) 192 (55%) 0.61 (0.45–0.83)
  1. The Caucasoid sample population refers to the combination of the following population samples: Greek, Spanish, Russian, and American (Whites). The non-Caucasoid sample population refers to the combination of the following population samples: North American (Amerinds), North American (Blacks), Bushmen, Korean, Chinese, and Javanese. The combined odds ratios (ORs) and 95% confidence intervals (CIs) evaluate the significance of the global effect of the different HLA-DRB1 allele groups on rheumatoid arthritis (RA) susceptibility in Caucasoids and non-Caucasoids.