Arthritis Research & Therapy

Table 5 Years of exposure to disease-modifying antirheumatic drugs and cardiovascular morbidity in patients with rheumatoid arthritis in the QUEST-RA study

From: Cardiovascular disease in patients with rheumatoid arthritis: results from the QUEST-RA study

	HR^a (95% CI) CV all types	HR^b (95% CI) CV all types	HR^c (95% CI)
			CV all types	Myocardial infarction	Stroke
Methotrexate	0.82 (0.79–0.86)^d	0.84 (0.80–0.87)^d	0.85 (0.81–0.89)^d	0.82 (0.74–0.91)^d	0.89 (0.82–0.98)^e
Glucocorticoids	0.94 (0.92–0.97)^d	0.95 (0.93–0.97)^d	0.95 (0.92–0.98)^d	0.96 (0.91–1.00)	0.98 (0.93–1.03)
Antimalarials	0.94 (0.91–0.98)^f	0.95 (0.91–0.99)^f	0.98 (0.94–1.02)	0.94 (0.85–1.03)	0.87 (0.76–1.01)
Sulfasalazine	0.91 (0.87–0.96)^d	0.92 (0.88–0.97)^f	0.92 (0.87–0.98)^f	0.82 (0.69–0.98)^e	0.90 (0.79–1.03)
Gold	0.96 (0.92–1.00)^e	0.96 (0.92–1.00)^e	0.99 (0.95–1.03)	1.04 (0.98–1.10)	0.98 (0.89–1.07)
Leflunomide	0.52 (0.38–0.72)^d	0.55 (0.41–0.75)^d	0.59 (0.43–0.79)^f	0.52 (0.26–1.06)	0.91 (0.65–1.28)
TNF-α blockers	0.67 (0.53–0.85)^f	0.71 (0.56–0.89)^f	0.64 (0.49–0.83)^f	0.42 (0.21–0.81)^e	0.64 (0.39–1.05)

^aCrude hazard ratio. ^bAdjusted hazard ratio by age and gender. ^cAdjusted hazard ratio by age, gender, disease activity/severity (DAS 28 [disease activity score using 28 joint counts] and Health Assessment Questionnaire), rheumatoid arthritis characteristics (rheumatoid factor-positive and extra-articular manifestations), and traditional cardiovascular risk factors (hypertension, hyperlipidemia, diabetes, smoking ever, and obesity). ^dP < 0.001. ^eP < 0.05. ^fP < 0.01. CI, confidence interval; CV, cardiovascular; QUEST-RA, Questionnaires in Standard Monitoring of Patients with Rheumatoid Arthritis; TNF-α, tumor necrosis factor-alpha.

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