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Table 5 Years of exposure to disease-modifying antirheumatic drugs and cardiovascular morbidity in patients with rheumatoid arthritis in the QUEST-RA study

From: Cardiovascular disease in patients with rheumatoid arthritis: results from the QUEST-RA study

  HRa (95% CI) CV all types HRb (95% CI) CV all types HRc (95% CI)
    CV all types Myocardial infarction Stroke
Methotrexate 0.82 (0.79–0.86)d 0.84 (0.80–0.87)d 0.85 (0.81–0.89)d 0.82 (0.74–0.91)d 0.89 (0.82–0.98)e
Glucocorticoids 0.94 (0.92–0.97)d 0.95 (0.93–0.97)d 0.95 (0.92–0.98)d 0.96 (0.91–1.00) 0.98 (0.93–1.03)
Antimalarials 0.94 (0.91–0.98)f 0.95 (0.91–0.99)f 0.98 (0.94–1.02) 0.94 (0.85–1.03) 0.87 (0.76–1.01)
Sulfasalazine 0.91 (0.87–0.96)d 0.92 (0.88–0.97)f 0.92 (0.87–0.98)f 0.82 (0.69–0.98)e 0.90 (0.79–1.03)
Gold 0.96 (0.92–1.00)e 0.96 (0.92–1.00)e 0.99 (0.95–1.03) 1.04 (0.98–1.10) 0.98 (0.89–1.07)
Leflunomide 0.52 (0.38–0.72)d 0.55 (0.41–0.75)d 0.59 (0.43–0.79)f 0.52 (0.26–1.06) 0.91 (0.65–1.28)
TNF-α blockers 0.67 (0.53–0.85)f 0.71 (0.56–0.89)f 0.64 (0.49–0.83)f 0.42 (0.21–0.81)e 0.64 (0.39–1.05)
  1. aCrude hazard ratio. bAdjusted hazard ratio by age and gender. cAdjusted hazard ratio by age, gender, disease activity/severity (DAS 28 [disease activity score using 28 joint counts] and Health Assessment Questionnaire), rheumatoid arthritis characteristics (rheumatoid factor-positive and extra-articular manifestations), and traditional cardiovascular risk factors (hypertension, hyperlipidemia, diabetes, smoking ever, and obesity). dP < 0.001. eP < 0.05. fP < 0.01. CI, confidence interval; CV, cardiovascular; QUEST-RA, Questionnaires in Standard Monitoring of Patients with Rheumatoid Arthritis; TNF-α, tumor necrosis factor-alpha.