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Table 1 Genetic factors confirmed for or suggestive of association with anticitrulline-peptide antibody (ACPA)-positive and ACPA-negative rheumatoid arthritis

From: Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets

Factor ACPA-positive rheumatoid arthritis ACPA-negative rheumatoid arthritis
Confirmed Human leucocyte antigen shared epitope alleles Human leucocyte antigen DR3
  Protein tyrosine phosphatase nonreceptor 22 (PTPN22)  
  Complement component 5-TNF receptor-associated factor 1 (C5-TRAF1)  
  TNFα-induced protein 3-oligodendrocyte lineage transcription factor 3 (TNFAIP3-OLIG3)  
Suggestive Cytotoxic T lymphocyte antigen 4 (CTLA4) Interferon regulatory factor 5 (IRF5)
  Signal transducer and activator of transcription 4 (STAT4)