Table 1 Genetic factors confirmed for or suggestive of association with anticitrulline-peptide antibody (ACPA)-positive and ACPA-negative rheumatoid arthritis
Factor | ACPA-positive rheumatoid arthritis | ACPA-negative rheumatoid arthritis |
|---|---|---|
Confirmed | Human leucocyte antigen shared epitope alleles | Human leucocyte antigen DR3 |
| Â | Protein tyrosine phosphatase nonreceptor 22 (PTPN22) | Â |
| Â | Complement component 5-TNF receptor-associated factor 1 (C5-TRAF1) | Â |
|  | TNFα-induced protein 3-oligodendrocyte lineage transcription factor 3 (TNFAIP3-OLIG3) |  |
Suggestive | Cytotoxic T lymphocyte antigen 4 (CTLA4) | Interferon regulatory factor 5 (IRF5) |
| Â | Signal transducer and activator of transcription 4 (STAT4) | Â |