| |
Control individuals
|
All JRA patients
|
JRA subgroups
| |
|---|
| | | |
Polyarthritis
|
Oligoarthritis
|
|
Exon 1 mutations
| | | | |
|
Sum A/A
|
120 (62)
|
128 (59)
|
43(64)
|
85 (56)
|
|
Sum A/O
|
65 (33)
|
81 (37)
|
22 (33)
|
59 (39)
|
|
A/B
|
40 (21)
|
43 (20)
|
14 (21)
|
29 (19)
|
|
A/C
|
5 (3)
|
7 (3)
|
0 (0)
|
7 (5)
|
|
A/D
|
20 (10)
|
31 (14)
|
8 (12)
|
23 (15)
|
|
Sum O/O
|
9 (5)
|
9 (4)
|
2 (2)
|
7 (5)
|
|
B/B
|
4 (2)
|
4 (2)
|
1 (1)
|
3 (2)
|
|
B/C
|
1 (0)
|
0 (0)
|
0 (0)
|
0 (0)
|
|
B/D
|
2 (1)
|
3 (1)
|
1 (1)
|
2 (1)
|
|
C/D
|
0 (0)
|
1 (0)
|
0 (0)
|
1 (1)
|
|
D/D
|
2 (1)
|
1 (0)
|
0 (0)
|
1 (1)
|
|
Total
|
194 (100)
|
218 (100)
|
67 (100)
|
151 (100)
|
|
Genotype groups
| | | | |
|
High
|
110 (57)
|
113 (52)
|
36 (54)
|
77 (51)
|
|
YA/YA
|
60 (31)
|
62 (28)
|
21 (31)
|
41 (27)
|
|
YA/XA
|
50 (26)
|
51 (23)
|
15 (22)
|
36 (24)
|
|
Medium
|
52 (27)
|
71 (33)
|
23 (34)
|
48 (32)
|
|
XA/XA
|
10 (5)
|
15 (7)
|
7 (10)
|
8 (5)
|
|
YA/O
|
42 (22)
|
56 (26)
|
16 (24)
|
40 (27)
|
|
Low
|
32 (16)
|
34 (16)
|
8 (12)
|
26 (17)
|
|
XA/O
|
23 (12)
|
25 (12)
|
6 (9)
|
19 (13)
|
|
O/O
|
9 (4)
|
9 (4)
|
2 (3)
|
7 (5)
|
|
Total
|
194 (100)
|
218 (100)
|
67 (100)
|
151 (100)
|
|
MBL concentration
| | | | |
|
High
|
1.65 (1.20 to 2.69)
|
1.86 (1.23 to 3.26)
|
1.87 (1.14 to 3.15)
|
1.85 (1.32 to 3.67)
|
|
Medium
|
0.52 (0.40 to 0.92)
|
0.77 (0.38 to 1.41)
|
0.89 (0.32 to 1.79)
|
0.73 (0.38 to 1.43)
|
|
Low
|
0.04 (0.02 to 0.13)
|
0.07 (0.04 to 0.15)
|
0.10 (0.05 to 0.15)
|
0.07 (0.04 to 0.17)
|
- Norwegian Caucasian children with juvenile polyarthritis (n = 67) and oligoarthritis (n = 151) are compared with 194 healthy Dutch Caucasian adult control individuals. Values are expressed as number (%) or, for continuous variables, as median (interquartile range). Median mannose-binding lectin (MBL) concentrations and frequencies of exon 1 mutations and MBL2 genotype groups did not differ between all juvenile rheumatoid arthritis (JRA) patients and healthy control individuals or within the polyarthritis and oligoarthritis groups (P values > 0.05). A is the designation for wild-type; O is the common designation for the variant alleles B (codon 54), C (codon 57) and D (codon 52).
