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Table 2 MBL concentrations and MBL2 genotypes

From: Mannose-binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis: a cohort study

 

Control individuals

All JRA patients

JRA subgroups

 
   

Polyarthritis

Oligoarthritis

Exon 1 mutations

    

   Sum A/A

120 (62)

128 (59)

43(64)

85 (56)

   Sum A/O

65 (33)

81 (37)

22 (33)

59 (39)

A/B

40 (21)

43 (20)

14 (21)

29 (19)

A/C

5 (3)

7 (3)

0 (0)

7 (5)

A/D

20 (10)

31 (14)

8 (12)

23 (15)

   Sum O/O

9 (5)

9 (4)

2 (2)

7 (5)

B/B

4 (2)

4 (2)

1 (1)

3 (2)

B/C

1 (0)

0 (0)

0 (0)

0 (0)

B/D

2 (1)

3 (1)

1 (1)

2 (1)

C/D

0 (0)

1 (0)

0 (0)

1 (1)

D/D

2 (1)

1 (0)

0 (0)

1 (1)

   Total

194 (100)

218 (100)

67 (100)

151 (100)

Genotype groups

    

   High

110 (57)

113 (52)

36 (54)

77 (51)

YA/YA

60 (31)

62 (28)

21 (31)

41 (27)

YA/XA

50 (26)

51 (23)

15 (22)

36 (24)

   Medium

52 (27)

71 (33)

23 (34)

48 (32)

XA/XA

10 (5)

15 (7)

7 (10)

8 (5)

YA/O

42 (22)

56 (26)

16 (24)

40 (27)

   Low

32 (16)

34 (16)

8 (12)

26 (17)

XA/O

23 (12)

25 (12)

6 (9)

19 (13)

O/O

9 (4)

9 (4)

2 (3)

7 (5)

   Total

194 (100)

218 (100)

67 (100)

151 (100)

MBL concentration

    

   High

1.65 (1.20 to 2.69)

1.86 (1.23 to 3.26)

1.87 (1.14 to 3.15)

1.85 (1.32 to 3.67)

   Medium

0.52 (0.40 to 0.92)

0.77 (0.38 to 1.41)

0.89 (0.32 to 1.79)

0.73 (0.38 to 1.43)

   Low

0.04 (0.02 to 0.13)

0.07 (0.04 to 0.15)

0.10 (0.05 to 0.15)

0.07 (0.04 to 0.17)

  1. Norwegian Caucasian children with juvenile polyarthritis (n = 67) and oligoarthritis (n = 151) are compared with 194 healthy Dutch Caucasian adult control individuals. Values are expressed as number (%) or, for continuous variables, as median (interquartile range). Median mannose-binding lectin (MBL) concentrations and frequencies of exon 1 mutations and MBL2 genotype groups did not differ between all juvenile rheumatoid arthritis (JRA) patients and healthy control individuals or within the polyarthritis and oligoarthritis groups (P values > 0.05). A is the designation for wild-type; O is the common designation for the variant alleles B (codon 54), C (codon 57) and D (codon 52).