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Table 2 MBL concentrations and MBL2 genotypes

From: Mannose-binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis: a cohort study

  Control individuals All JRA patients JRA subgroups  
    Polyarthritis Oligoarthritis
Exon 1 mutations     
   Sum A/A 120 (62) 128 (59) 43(64) 85 (56)
   Sum A/O 65 (33) 81 (37) 22 (33) 59 (39)
A/B 40 (21) 43 (20) 14 (21) 29 (19)
A/C 5 (3) 7 (3) 0 (0) 7 (5)
A/D 20 (10) 31 (14) 8 (12) 23 (15)
   Sum O/O 9 (5) 9 (4) 2 (2) 7 (5)
B/B 4 (2) 4 (2) 1 (1) 3 (2)
B/C 1 (0) 0 (0) 0 (0) 0 (0)
B/D 2 (1) 3 (1) 1 (1) 2 (1)
C/D 0 (0) 1 (0) 0 (0) 1 (1)
D/D 2 (1) 1 (0) 0 (0) 1 (1)
   Total 194 (100) 218 (100) 67 (100) 151 (100)
Genotype groups     
   High 110 (57) 113 (52) 36 (54) 77 (51)
YA/YA 60 (31) 62 (28) 21 (31) 41 (27)
YA/XA 50 (26) 51 (23) 15 (22) 36 (24)
   Medium 52 (27) 71 (33) 23 (34) 48 (32)
XA/XA 10 (5) 15 (7) 7 (10) 8 (5)
YA/O 42 (22) 56 (26) 16 (24) 40 (27)
   Low 32 (16) 34 (16) 8 (12) 26 (17)
XA/O 23 (12) 25 (12) 6 (9) 19 (13)
O/O 9 (4) 9 (4) 2 (3) 7 (5)
   Total 194 (100) 218 (100) 67 (100) 151 (100)
MBL concentration     
   High 1.65 (1.20 to 2.69) 1.86 (1.23 to 3.26) 1.87 (1.14 to 3.15) 1.85 (1.32 to 3.67)
   Medium 0.52 (0.40 to 0.92) 0.77 (0.38 to 1.41) 0.89 (0.32 to 1.79) 0.73 (0.38 to 1.43)
   Low 0.04 (0.02 to 0.13) 0.07 (0.04 to 0.15) 0.10 (0.05 to 0.15) 0.07 (0.04 to 0.17)
  1. Norwegian Caucasian children with juvenile polyarthritis (n = 67) and oligoarthritis (n = 151) are compared with 194 healthy Dutch Caucasian adult control individuals. Values are expressed as number (%) or, for continuous variables, as median (interquartile range). Median mannose-binding lectin (MBL) concentrations and frequencies of exon 1 mutations and MBL2 genotype groups did not differ between all juvenile rheumatoid arthritis (JRA) patients and healthy control individuals or within the polyarthritis and oligoarthritis groups (P values > 0.05). A is the designation for wild-type; O is the common designation for the variant alleles B (codon 54), C (codon 57) and D (codon 52).