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Table 3 Association of demographic, clinical, and laboratory characteristics and MBL2 genotype expression groups: juvenile polyarthritis

From: Mannose-binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis: a cohort study

Characteristic MBL genotype expression groups    P a P b
  High (n = 36) Medium (n = 23) Low (n = 8)   
Demographic variables      
   Males 10 (28%) 4 (17%) 5 (63%) 0.05 0.04
   Age (years) at onset 9.5 (5.6 to 13.0) 10.1 (8.4 to 13.0) 4.4 (3.6 to 7.0) 0.03 <0.01
   Disease duration (years) at follow up 14.6 (13.5 to 16.3) 14.5 (13.2 to 16.4) 15.8 (13.4 to 16.6) NS NS
Clinical variables     NS NS
   Cumulative affected joints 18 (10 to 32) 22 (10 to 36) 23 (12 to 39) NS NS
   Actively involved joints 1 (0 to 4) 2 (0 to 8) 0 (0 to 2) NS NS
   Affected joints 6 (2 to 18) 8 (0 to 20) 8 (1 to 27) NS NS
   Arthritis severity index 10 (2 to 31) 17 (0 to 46) 19 (2 to 54) NS NS
   Physician global assessment 2 (1 to 3) 2 (1 to 4) 1 (1 to 2) NS NS
   Childhood Health Assessment Questionnaire score 0.1 (0.0 to 0.6) 0.3 (0.0 to 1.2) 0 (0.0 to 0.3) NS NS
   Patients with uveitis 5 (14%) 4 (17%) 1 (13%) NS NS
   Remission status at follow up     NS NS
Current remission 18 (50%) 10 (44%) 4 (50%)   
Active, but previous remission 8 (22%) 4 (17%) 2 (25%)   
Continuously active 10 (28%) 9 (39%) 2 (25%)   
   Radiographic erosions grade III to IV 16 (44%) 10 (44%) 4 (50%) NS NS
Laboratory variables     NS NS
   Erythrocyte sedimentation rate (mm/hour) 8 (4 to 20) 8 (5 to 25) 3 (0 to 23) NS NS
   C-reactive protein (mg/l) 5 (3 to 9) 7 (3 to 18) 5 (4 to 17) NS NS
   Antinuclear antibody positivity 10 (28%) 6 (27%) 1 (13%) NS NS
   IgM-rheumatoid factor positivity 4 (11%) 7 (30%) 0 (0%) NS NS
  1. Included in this analysis are 67 patients with juvenile polyarthritis. Values are expressed as number (%) or, for continuous variables, as median (interquartile range). aComparison of the high, medium and low genotype expression groups by means of the two-sided Fisher's exact test and Kruskal-Wallis test. bComparison of the high and medium genotype group versus the low genotype expression group by means of the two-sided Fisher's exact test and Mann-Whitney U-test. NS, not significant.