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Table 1 Expression of activation markers, adhesion molecules and chemokine receptors in CD4+CD45RO+ Tck cells

From: Resting CD4+effector memory T cells are precursors of bystander-activated effectors: a surrogate model of rheumatoid arthritis synovial T-cell function

Cell phenotype Median MFI (range)/percentage positive (%) index Changea P n
  Day 0 Day 8    
CD25 8.0 (2–49)/9% 61 (6–884)/18% 7.5 <0.0001 40
CD69 5.0 (2–43)/1.1% 41 (5–552)/26.7% 8 <0.0001 41
HLA-DR 19 (4–130)/9% 60 (11–238)/15% 3 0.0052 15
CD62L 22 (8–255)/17% 339 (7–1,040)/58% 15 <0.0001 31
CD18 107 (9–1,026)/97.5% 319 (53–2,040)/98.5% 3 0.0085 21
CD29 85 (6–668)/81% 152 (14–582)/97% 2 0.0132 35
CD49d 180 (5–634)/73.3% 465 (13–1,461)/82.3% 2.6 <0.0001 42
CCR7 12 (4–57)/7.4% 13 (3–138)/8.6% 1 NS 42
CXCR4 52 (18–494)/29% 270 (124–896)/86.4% 5 <0.0001 21
CXCR3 32.3 (9–309)/34.3% 40.4 (17–129)/34.0% 1 NS 21
CCR5 8.3 (4–28)/2% 10.7 (4–262)/6% 1 NS 21
  1. Statistically significant differences in mean fluorescence intensity (MFI) between day 0 and day 8 values from different experiments were calculated using Wilcoxon rank test. aChange index is calculated with reference to Day 0. CCR, CC chemokine receptor; CXCR, CXC chemokine receptor; HLA, human leucocyte antigen; NS, not significant; Tck, cytokine-activated T.