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Figure 5 | Arthritis Research & Therapy

Figure 5

From: TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood

Figure 5

TNF injection decreases stromal cell-derived factor 1 expression by bone marrow stromal cells. Expression of stromal cell-derived factor 1 (SDF-1) protein by bone marrow cells was examined by immunostaining with anti-SDF-1 antibody. Left panels: pictures taken at power 2 to show the overall view of bone architecture. Right panels: pictures are the insert taken at power 20 to show SDF-1-positive bone marrow osteoblasts (upper panel arrows) in mice receiving PBS injection and to show SDF-1-negative cells (lower panel arrows) in TNF-injected mice. Photographs are representatives of one pair of TNF-injected or PBS-injected mice from three pairs of animals.

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Arthritis Research & Therapy

ISSN: 1478-6362

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