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Table 2 Fatty acid amide hydrolase (FAAH) activity in synovial tissue from osteoarthritis (n = 5) and rheumatoid arthritis (n = 4) patients

From: Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis

  FAAH activity (pmol/minute/mg protein)
Tissue Control + URB597
Osteoarthritis synovium 2.8 ± 0.46 Undetectable
Rheumatoid arthritis synovium 1.6 ± 0.42 Undetectable
Rat liver 988 ± 84 1.28 ± 0.51
  1. FAAH activity was measured by monitoring the release of [3H]-ethanolamine after incubation of homogenates with [3H]-anandamide. Each sample was processed in three separate experiments. Data are presented as mean ± standard error of the mean. URB597, 3'-(aminocarbonyl) [1,1'-biphenyl]-3-yl)-cyclohexylcarbamate.