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Table 1 The major phenotypes of bovine intervertebral disc cells in response to altered culture conditions

From: The influence of serum, glucose and oxygen on intervertebral disc cell growth in vitro: implications for degenerative disc disease

  Serum Glucose
Monolayer With Without With Without
Cell proliferation ↑↑↑ ↓↓ ↑↑↑↑
Cell senescence ↑↑↑
Cell death
Collagen synthesis ↑↑↑ Type I ↓ Type II ↔ Type I ↔ Type II ↔ Type I ↔ Type II ↓↓↓ Type I ↓ Type II
  Serum Glucose
Alginate With Without With Without
Cell proliferation ↓↓ ↓↓↓
Cell senescence ↑↑
Cell death ↓↓
Collagen synthesis ↓ Type I ↑↑ Type II ↔ Type I ↔ Type II ↔ Type I ↔ Type II ↔ Type I ↓↓ Type II
  1. ↑, increased; ↓, decreased; ↔, no change (from control conditions).