Arthritis Research & Therapy

Table 1 The major phenotypes of bovine intervertebral disc cells in response to altered culture conditions

From: The influence of serum, glucose and oxygen on intervertebral disc cell growth in vitro: implications for degenerative disc disease

	Serum		Glucose
Monolayer	With	Without	With	Without
Cell proliferation	↑↑↑	↓↓	↔	↑↑↑↑
Cell senescence	↔	↑↑↑	↔	↔
Cell death	↔	↔	↔	↔
Collagen synthesis	↑↑↑ Type I ↓ Type II	↔ Type I ↔ Type II	↔ Type I ↔ Type II	↓↓↓ Type I ↓ Type II
	Serum		Glucose
Alginate	With	Without	With	Without
Cell proliferation	↓↓	↓↓↓	↔	↑
Cell senescence	↔	↑↑	↔	↔
Cell death	↔	↓↓	↔	↔
Collagen synthesis	↓ Type I ↑↑ Type II	↔ Type I ↔ Type II	↔ Type I ↔ Type II	↔ Type I ↓↓ Type II

↑, increased; ↓, decreased; ↔, no change (from control conditions).

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ISSN: 1478-6362

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