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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Prolonged, granulocyte–macrophage colony-stimulating factor-dependent, neutrophil survival following rheumatoid synovial fibroblast activation by IL-17 and TNFalpha

Figure 1

IL-17 expression on T cells within rheumatoid synovium and in synovial fluid CD4+CD3+ T cells. (a) Rheumatoid synovial tissue was examined by immunohistochemistry. IL-17 (red) was found to colocalise with CD3+ T cells (blue) in perivascular cuffs (purple). Blood vessels were localised with von Willebrand factor (vWF) (green). Nuclear staining is shown in grey. (b) IL-17 (red) expression is associated with CD4+ T cells (blue) but not CD8+ (green) T cells. Nuclear staining is shown in grey. (c) flow cytometric analysis of peripheral blood (PB) and synovial fluid (SF) CD3+ T cells demonstrates that IL-17 is expressed in SF CD4+ T cells. PE, phycoerythrin; FITC, fluorescein isothyocyanate.

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Arthritis Research & Therapy

ISSN: 1478-6362

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