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Table 1 Deaths reported in human gene therapy trials

From: Arthritis gene therapy's first death

Year

Disease target

Vector

Comment

Death related to gene therapy?

Ref.

1999

Ornithine transcarbamylase deficiency

Adenovirus

Patient died within 4 days from cytokine storm elicited by infusion of vector

Yes

[3]

2002

X-linked severe combined immunodeficiency

Retrovirus

Leukemia developed, linked to insertion of retrovirus adjacent to the LMO2 oncogene promoter

Yes

[5]

2006

X-linked chronic granulomatous disease

Retrovirus

Loss of transgene expression led to death from underlying disease

No

[7]

2007

Rheumatoid arthritis

Adeno-associated virus

Present article

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