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Table 1 Deaths reported in human gene therapy trials

From: Arthritis gene therapy's first death

Year Disease target Vector Comment Death related to gene therapy? Ref.
1999 Ornithine transcarbamylase deficiency Adenovirus Patient died within 4 days from cytokine storm elicited by infusion of vector Yes [3]
2002 X-linked severe combined immunodeficiency Retrovirus Leukemia developed, linked to insertion of retrovirus adjacent to the LMO2 oncogene promoter Yes [5]
2006 X-linked chronic granulomatous disease Retrovirus Loss of transgene expression led to death from underlying disease No [7]
2007 Rheumatoid arthritis Adeno-associated virus Present article