Year | Disease target | Vector | Comment | Death related to gene therapy? | Ref. |
---|---|---|---|---|---|
1999 | Ornithine transcarbamylase deficiency | Adenovirus | Patient died within 4 days from cytokine storm elicited by infusion of vector | Yes | [3] |
2002 | X-linked severe combined immunodeficiency | Retrovirus | Leukemia developed, linked to insertion of retrovirus adjacent to the LMO2 oncogene promoter | Yes | [5] |
2006 | X-linked chronic granulomatous disease | Retrovirus | Loss of transgene expression led to death from underlying disease | No | [7] |
2007 | Rheumatoid arthritis | Adeno-associated virus | Present article | Â | Â |