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Figure 3 | Arthritis Research & Therapy

Figure 3

From: T cells in rheumatoid arthritis

Figure 3

Pathway biology: the impact of RA-associated allelic variants. Multiple single nucleotide polymorphisms may contribute to the disease-prone state through subtle modifications in antigen presentation ('single input') and T-cell antigen receptor responsiveness ('signal output'). It is proposed that these variants may influence multiple pathways of T-cell activation, differentiation, and effector function. DC, dendritic cell; RA, rheumatoid arthritis; TCR, T-cell receptor; Teff, effector T cell; Th, T-helper cell.

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