Table 1 Markers of degradation of cartilage and bone
Tissue | Molecule | Marker of degradation | Designation |
|---|---|---|---|
Cartilage | Type II collagen | Pyridinoline | PYD |
| Â | Â | Type II collagen C-terminal and N-terminal telopeptides | CTX-II, NTX-II |
| Â | Â | Type II collagen alpha chain fragments | Col2-3/4 long, Col2-3/4C short |
| Â | Aggrecan | Core protein fragments | Â |
| Â | Â | Keratan sulfate fragments | Â |
| Â | Noncollagen and nonaggrecan proteins | Cartilage oligomeric matrix protein | COMP |
Bone | Type I collagen | Pyridinoline, deoxypyridinolin | PYD, DPD |
| Â | Â | Type I collagen C-terminal and N-terminal telopeptides | CTX-I, NTX-I |
| Â | Noncollagenous proteins | Bone sialoprotein | BSP |
| Â | Â | Tartrate-resistant acid phosphatase | TRAP |