Molecular discrimination of responders and nonresponders to anti-TNFalpha therapy in rheumatoid arthritis by etanercept

Table 4 Combinations of genes predictive for the clinical outcome: gene pairs and gene triplets

Combination	Gene 1		Gene 2		Gene 3		Q (%)
Gene pair
1	TNFAIP3	202643_s_at	RAPGEF1	204543_at			90.5
2	TNFAIP3	202643_s_at	PTPRD	205712_at			90.5
3	TNFAIP3	202644_s_at	PTPRD	205712_at			90.5
4	IL1B	205067_at	LGALS13	220440_at			90.5
5	CCL4	204103_at	ADAM12	215613_at			89.5
6	ADAM12	215613_at	CCL3	205114_s_at			89.5
7	FSD1	219170_at	HCG4P6	215974_at			89.5
Gene triplet
1	CCL4	204103_at	PDE4B	211302_s_at	RAPGEF1	204543_at	99.0
2	PDE4B	211302_s_at	RAPGEF1	204543_at	CXCR4	211919_s_at	98.0
3	CCL4	204103_at	PIGO	214990_at	RAPGEF1	204543_at	96.8
4	CCL4	204103_at	FSD1	219170_at	RAPGEF1	204543_at	96.8
5	CCL4	204103_at	CCL3	205114_s_at	RAPGEF1	204543_at	96.8
6	PDE4B	211302_s_at	RUNX1	211620_x_at	RAPGEF1	204543_at	96.8
7	CCL4	204103_at	LGALS13	220440_at	RAPGEF1	204543_at	95.8
8	TNFAIP3	202643_s_at	CCL4	204103_at	RAPGEF1	204543_at	95.8
9	TNFAIP3	202643_s_at	PDE4B	211302_s_at	RAPGEF1	204543_at	95.8
10	TNFAIP3	202644_s_at	PDE4B	211302_s_at	RAPGEF1	204543_at	95.8

Gene pairs and triplets of genes with prognostic relevance for etanercept therapy in rheumatoid arthritis determined using support vector machines based on 46 selected probe sets of differentially regulated genes. Gene pairs with prediction accuracy Q > 89% and triplets of genes with prediction accuracy Q > 95% are shown. For gene function refer to Table 3.

ISSN: 1478-6362