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Table 6 Gene expression analysis by real-time quantitative RT-PCR

From: Molecular discrimination of responders and nonresponders to anti-TNFalpha therapy in rheumatoid arthritis by etanercept

Gene

Responder

Nonresponder

P value

NFKBIA

-0.227

(± 0.749)

1.053

(± 1.128)

0.008

CCL4

-0.142

(± 1.184)

1.144

(± 0.924)

0.025

IL8

-0.025

(± 1.871)

2.429

(± 2.489)

0.028

IL1B

-0.595

(± 1.680)

1.487

(± 2.191)

0.032

TNFAIP3

0.002

(± 0.895)

1.266

(± 1.510)

0.034

PDE4B

-0.276

(± 0.846)

0.534

(± 0.544)

0.037

PPP1R15A

-0.280

(± 0.935)

0.825

(± 1.225)

0.040

ADM

-0.931

(± 1.289)

0.279

(± 1.016)

0.049

  1. Data shown are the changes of gene expression (-ΔΔCT t1 versus t0; mean ± standard deviation) of eight selected genes averaged over the 12 responders and seven nonresponders, and the corresponding P values determined by two-sample t test comparing the means of responders and nonresponders.