Table 6 PTPN22 genotype and smoking interactions according to RF status in NHS/NHSII pooled samples

Smoking status

   Never

CC

1.00 (ref.)

1.00 (ref.)

1.00 (ref.)

   Ever

CC

1.10 (0.79–1.53)

1.37 (0.93–2.01)

1.02 (0.68–1.53)

   Never

CT/TT

1.07 (0.61–1.86)

1.57 (0.86–2.87)

0.87 (0.43–1.77)

   Ever

CT/TT

1.90 (1.14–3.16)

2.56 (1.47–4.46)

1.67 (0.91–3.06)

   Additive interaction

AP = 0.39 (95% CI -0.04 to +0.82); P_add^e = 0.08

AP = 0.24 (95% CI -0.26 to +0.75); P_add^e = 0.35

AP = 0.47 (95% CI -0.03 to +0.96); P_add^e = 0.07

   Multiplicative interaction

P_multi^f = 0.20

P_multi^f = 0.67

P_multi^f = 0.18

Pack-years smoking

   <10

CC

1.00 (ref.)

1.00 (ref.)

1.00 (ref.)

   >10

CC

1.25 (0.89–1.75)

1.40 (0.96–2.05)

1.22 (0.81–1.83)

   <10

CT/TT

1.09 (0.69–1.73)

1.48 (0.89–2.47)

1.00 (0.55–1.82)

   >10

CT/TT

3.05 (1.64–5.66)

3.27 (1.74–6.15)

2.50 (1.25–5.00)

   Additive interaction

AP = 0.56 (95% CI 0.24 to 0.88); P_add^e = 0.0006

AP = 0.42 (95% CI 0.01 to 0.84); P_add^e = 0.04

AP = 0.51 (95% CI 0.09 to 0.93); P_add^e = 0.02

   Multiplicative interaction

P_multi^f = 0.04

P_multi^f = 0.28

P_multi^f = 0.13